{"id":"6c888aba-2a0e-5b82-8c21-98e4660e0475","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-stra6-rbp-binding","predicate":"binds","statement":"STRA6 was identified as a high-affinity membrane receptor for retinol-binding protein.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"76f4b27c-71be-54f6-8200-390d7dc5d7dc","mechanism_event_label":"Cells recognize circulating retinol through its carrier protein.","subject":{"id":"dae8de03-841b-57f1-8fbd-9b20401a80d1","slug":"stra6","display_name":"Retinol uptake receptor STRA6","entity_type_key":"protein"},"object":{"id":"fa1220a6-1bfb-5a15-b57f-65e5d2135b19","slug":"holo-rbp4","display_name":"Retinol-loaded RBP4","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"76f4b27c-71be-54f6-8200-390d7dc5d7dc","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-stra6-rbp-binding-event","event_type":"biochemical_relationship","label":"Cells recognize circulating retinol through its carrier protein.","description":"STRA6 was identified as a high-affinity membrane receptor for retinol-binding protein.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"148c57d8-c658-5769-89e8-1194cef2a782","slug":"retinol","display_name":"All-trans-retinol","entity_type_key":"small_molecule"},"role":"carrier-bound-cargo","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dae8de03-841b-57f1-8fbd-9b20401a80d1","slug":"stra6","display_name":"Retinol uptake receptor STRA6","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fa1220a6-1bfb-5a15-b57f-65e5d2135b19","slug":"holo-rbp4","display_name":"Retinol-loaded RBP4","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_location","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Receptor isolation from bovine retinal pigment epithelium and cellular uptake assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"RBP-binding purification and receptor-expression assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Identification in RPE does not make STRA6 mandatory for every tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Bos taurus receptor-isolation material and transfected cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"outcome","value_text":"STRA6 was identified as a high-affinity membrane receptor for retinol-binding protein.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Cells recognize circulating retinol through its carrier protein.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-kawaguchi-2007] A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A (2007). https://pubmed.ncbi.nlm.nih.gov/17255476/ DOI: 10.1126/science.1136244","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Retinal pigment epithelium and plasma membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"639d14da-db13-5333-8560-9a0c5e32ccac","evidence_kind":"source_excerpt","locator":"Lines 430-442","start_line":430,"end_line":442,"excerpt":"### va-stra6-rbp-binding\nSTRA6 was identified as a high-affinity membrane receptor for retinol-binding protein.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Cells recognize circulating retinol through its carrier protein.\norganism: Bos taurus receptor-isolation material and transfected cells\ntissue_or_cell_type: Retinal pigment epithelium and plasma membrane\nexperimental_model: Receptor isolation from bovine retinal pigment epithelium and cellular uptake assays.\nlimitations: Identification in RPE does not make STRA6 mandatory for every tissue.\nexposure: RBP-binding purification and receptor-expression assays.\noutcome: STRA6 was identified as a high-affinity membrane receptor for retinol-binding protein.\nevidence_location: Abstract\n[va-kawaguchi-2007] A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A (2007). https://pubmed.ncbi.nlm.nih.gov/17255476/ DOI: 10.1126/science.1136244","model_system":"Receptor isolation from bovine retinal pigment epithelium and cellular uptake assays.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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