{"id":"6c7310d6-ee9e-53fa-b473-51cc37e80b20","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-neuro-treatment-response","predicate":"replacement_followed_by_neurologic_improvement","statement":"Among the 40 patients lacking at least one blood-count abnormality, one died in the first week; all 39 remaining patients showed neuropsychiatric improvement following cobalamin therapy.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"5b880be3-0765-52c9-80ad-cf25aaabfda2","mechanism_event_label":"A blood count could look unremarkable while a B12-responsive nervous-system problem was present.","subject":{"id":"b6d9b937-895d-5e0a-8cc5-0454a0b7d373","slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"},"object":{"id":"e058a824-b021-58a0-bcde-d9fb7883b142","slug":"b12-neurologic-recovery","display_name":"Neurologic recovery following B12 replacement","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5b880be3-0765-52c9-80ad-cf25aaabfda2","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-neuro-treatment-response-event","event_type":"observed_intervention","label":"A blood count could look unremarkable while a B12-responsive nervous-system problem was present.","description":"Among the 40 patients lacking at least one blood-count abnormality, one died in the first week; all 39 remaining patients showed neuropsychiatric improvement following cobalamin therapy.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b6d9b937-895d-5e0a-8cc5-0454a0b7d373","slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e058a824-b021-58a0-bcde-d9fb7883b142","slug":"b12-neurologic-recovery","display_name":"Neurologic recovery following B12 replacement","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Clinical series: 141 consecutive patients with neuropsychiatric abnormalities attributed to cobalamin deficiency; 40 lacked anemia or macrocytosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Clinical evaluation and cobalamin replacement; observational response series.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Uncontrolled selected series; response does not mean complete recovery or prove that every neuropsychiatric symptom is caused by B12.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A blood count could look unremarkable while a B12-responsive nervous-system problem was present.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b12-lindenbaum1988] Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis (1988). https://pubmed.ncbi.nlm.nih.gov/3374544/ DOI: 10.1056/nejm198806303182604","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"c4065abf-6f7d-523c-b9e2-9af3767dd017","evidence_kind":"source_excerpt","locator":"Lines 1438-1448","start_line":1438,"end_line":1448,"excerpt":"### b12-neuro-treatment-response\nAmong the 40 patients lacking at least one blood-count abnormality, one died in the first week; all 39 remaining patients showed neuropsychiatric improvement following cobalamin therapy.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A blood count could look unremarkable while a B12-responsive nervous-system problem was present.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Clinical series: 141 consecutive patients with neuropsychiatric abnormalities attributed to cobalamin deficiency; 40 lacked anemia or macrocytosis.\nlimitations: Uncontrolled selected series; response does not mean complete recovery or prove that every neuropsychiatric symptom is caused by B12.\nexposure: Clinical evaluation and cobalamin replacement; observational response series.\n[b12-lindenbaum1988] Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis (1988). https://pubmed.ncbi.nlm.nih.gov/3374544/ DOI: 10.1056/nejm198806303182604","model_system":"Clinical series: 141 consecutive patients with neuropsychiatric abnormalities attributed to cobalamin deficiency; 40 lacked anemia or macrocytosis.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b12-lindenbaum1988] Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis (1988). https://pubmed.ncbi.nlm.nih.gov/3374544/ DOI: 10.1056/nejm198806303182604","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73145023-2982-5848-aff2-8d8875d6b9c5","stable_key":"import-7fc92b9e-9cbf-556e-8719-6b5244625250","title":"Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ad5b3a51d36e856aa7fdfd1cc23f690b094689bad87d28e1a621a54675a01c92","revision_id":"118bd616-0c13-549f-bfeb-bc439715b89c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}