{"id":"6c5affee-4a28-5efc-8e03-4a98f05610d1","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-trained-3g","predicate":"does_not_increase_tested","statement":"In resistance-trained men, 3 g/day D-aspartic acid for 28 days did not improve testosterone, strength or body composition relative to placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"195e8e9c-75d7-5a53-a34f-299ed05926bb","mechanism_event_label":"A later trained-population trial did not reproduce a testosterone increase.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"195e8e9c-75d7-5a53-a34f-299ed05926bb","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-trained-3g-event","event_type":"observed_relationship","label":"A later trained-population trial did not reproduce a testosterone increase.","description":"In resistance-trained men, 3 g/day D-aspartic acid for 28 days did not improve testosterone, strength or body composition relative to placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized blinded resistance-training trial; four training days per week.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different population, formulation and duration from the early sodium-salt study; absence of benefit here is not proof of no effect in every population.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A later trained-population trial did not reproduce a testosterone increase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24074738/ · DOI 10.1016/j.nutres.2013.07.010","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a7a83be6-2860-5592-8399-53cb7dd5c9ca","evidence_kind":"source_excerpt","locator":"Lines 336-342","start_line":336,"end_line":342,"excerpt":"## d-aspartate-human-trained-3g\nA later trained-population trial did not reproduce a testosterone increase.\nIn resistance-trained men, 3 g/day D-aspartic acid for 28 days did not improve testosterone, strength or body composition relative to placebo.\nModel: Randomized blinded resistance-training trial; four training days per week.\nLimitations: Different population, formulation and duration from the early sodium-salt study; absence of benefit here is not proof of no effect in every population.\nEvidence access: Primary abstract\nD-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. · 2013 · https://pubmed.ncbi.nlm.nih.gov/24074738/ · DOI 10.1016/j.nutres.2013.07.010","model_system":"Randomized blinded resistance-training trial; four training days per week.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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