{"id":"6bf7a1cc-7cd4-546a-af31-3c74173b81d3","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-zinc-proliferation","predicate":"stimulates","statement":"Zinc-carnosine increased HT29 proliferation in thymidine-incorporation assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d1b4af91-223c-5b84-a135-6be3eccac8e1","mechanism_event_label":"Cell growth was measured separately from migration.","subject":{"id":"a1ed4282-d9fa-5acb-94f3-d4cf19dfd693","slug":"zinc-carnosine","display_name":"Zinc L-carnosine complex / polaprezinc","entity_type_key":"chemical_species"},"object":{"id":"8074385c-6ac7-5911-b26e-7594e0747772","slug":"human-ht29-proliferation","display_name":"Human HT29 epithelial proliferation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d1b4af91-223c-5b84-a135-6be3eccac8e1","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-zinc-proliferation-event","event_type":"observed_relationship","label":"Cell growth was measured separately from migration.","description":"Zinc-carnosine increased HT29 proliferation in thymidine-incorporation assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a1ed4282-d9fa-5acb-94f3-d4cf19dfd693","slug":"zinc-carnosine","display_name":"Zinc L-carnosine complex / polaprezinc","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8074385c-6ac7-5911-b26e-7594e0747772","slug":"human-ht29-proliferation","display_name":"Human HT29 epithelial proliferation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human HT29 culture.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell proliferation is not universally beneficial and is not proof of whole-gut healing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Cell growth was measured separately from migration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. · 2007 · https://pubmed.ncbi.nlm.nih.gov/16777920/ · DOI 10.1136/gut.2006.099929","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"80804516-2129-5444-aded-4f411be1df1b","evidence_kind":"source_excerpt","locator":"Lines 364-370","start_line":364,"end_line":370,"excerpt":"## carnosine-zinc-proliferation\nCell growth was measured separately from migration.\nZinc-carnosine increased HT29 proliferation in thymidine-incorporation assays.\nModel: Human HT29 culture.\nLimitations: Cell proliferation is not universally beneficial and is not proof of whole-gut healing.\nEvidence access: Primary abstract\nZinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. · 2007 · https://pubmed.ncbi.nlm.nih.gov/16777920/ · DOI 10.1136/gut.2006.099929","model_system":"Human HT29 culture.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"469cbc38203db56bd031f9d8a2dd2bfa387713950ca30199511cd137e927aa7a","revision_id":"cc409a15-8b04-50ee-a7ff-d1bf32f686bb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}