{"id":"6b9e3a52-61d7-507e-8dd7-99bf37637547","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-rat-il6","predicate":"reduced","statement":"Lycopene downregulated local IL-6 expression in the rat tumor experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f8fdc869-1e7d-5c04-a0fe-3cebb9fc817f","mechanism_event_label":"An inflammatory signaling measurement also changed.","subject":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"object":{"id":"518419e0-04ec-5037-8c6c-e663ea44a51c","slug":"rat-prostate-il6-expression","display_name":"IL-6 expression in rat Dunning prostate tumors","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f8fdc869-1e7d-5c04-a0fe-3cebb9fc817f","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-rat-il6-event","event_type":"biochemical_relationship","label":"An inflammatory signaling measurement also changed.","description":"Lycopene downregulated local IL-6 expression in the rat tumor experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"518419e0-04ec-5037-8c6c-e663ea44a51c","slug":"rat-prostate-il6-expression","display_name":"IL-6 expression in rat Dunning prostate tumors","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/15084515.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"682a0c4c6a001993efa3bada4aa3d381723feb78b410fd703b8de72517eef62c\", \"start_char\": 0, \"end_char\": 1410, \"text_sha256\": \"682a0c4c6a001993efa3bada4aa3d381723feb78b410fd703b8de72517eef62c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary intervention and tumor gene-expression analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"200 ppm lycopene, 540 ppm vitamin E or both for four weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preclinical gene-expression findings; not established human steroid suppression or cancer treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat MatLyLu Dunning prostate tumor model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An inflammatory signaling measurement also changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p15084515] Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. (2004). https://pubmed.ncbi.nlm.nih.gov/15084515/ DOI: 10.1096/fj.03-1116fje","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Tumor tissue","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"735cece0-6042-51fb-93a8-60f596e92ccc","evidence_kind":"source_excerpt","locator":"Lines 923-934","start_line":923,"end_line":934,"excerpt":"### lycopene-rat-il6\nLycopene downregulated local IL-6 expression in the rat tumor experiment.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An inflammatory signaling measurement also changed.\norganism: Rat MatLyLu Dunning prostate tumor model\ntissue_or_cell_type: Tumor tissue\nexperimental_model: Dietary intervention and tumor gene-expression analysis\nlimitations: Preclinical gene-expression findings; not established human steroid suppression or cancer treatment.\nexposure: 200 ppm lycopene, 540 ppm vitamin E or both for four weeks\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/15084515.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"682a0c4c6a001993efa3bada4aa3d381723feb78b410fd703b8de72517eef62c\", \"start_char\": 0, \"end_char\": 1410, \"text_sha256\": \"682a0c4c6a001993efa3bada4aa3d381723feb78b410fd703b8de72517eef62c\"}\n[lycopene-p15084515] Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. (2004). https://pubmed.ncbi.nlm.nih.gov/15084515/ DOI: 10.1096/fj.03-1116fje","model_system":"Dietary intervention and tumor gene-expression analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lycopene-p15084515] Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. (2004). https://pubmed.ncbi.nlm.nih.gov/15084515/ DOI: 10.1096/fj.03-1116fje","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d1e09874-8bde-548f-9664-26ad5eedb3c7","stable_key":"import-aad5a443-96e9-52eb-963a-812e90f9f896","title":"Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"9a53dd877de8b71d446f741026477c0fd70a38edac89f6f25339a371a627a59a","revision_id":"2e68d88d-a689-5959-9f9c-1552dd089c22","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}