{"id":"6b354405-b25a-5486-8ab5-b02897e2528d","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-lemur-mortality","predicate":"did_not_significantly_reduce","statement":"In the 33-male RESTRIKAL cohort, long-term 200 mg/kg/day resveratrol did not significantly reduce all-cause or age-related mortality despite a higher observed median lifespan.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"097285e1-b3d3-5e1f-91dc-736cabf17021","mechanism_event_label":"A higher sample median is not automatically a demonstrated survival benefit.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"5c204074-ce53-5f8b-8256-de2edbbd858f","slug":"mouse-lemur-resveratrol-mortality","display_name":"Mortality in resveratrol-fed male mouse lemurs","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"097285e1-b3d3-5e1f-91dc-736cabf17021","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-lemur-mortality-event","event_type":"observed_relationship","label":"A higher sample median is not automatically a demonstrated survival benefit.","description":"In the 33-male RESTRIKAL cohort, long-term 200 mg/kg/day resveratrol did not significantly reduce all-cause or age-related mortality despite a higher observed median lifespan.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5c204074-ce53-5f8b-8256-de2edbbd858f","slug":"mouse-lemur-resveratrol-mortality","display_name":"Mortality in resveratrol-fed male mouse lemurs","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"18 resveratrol and 15 controls; lifelong follow-up.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small male-only nonhuman-primate cohort; earlier reports from this program are not independent samples.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A higher sample median is not automatically a demonstrated survival benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol does not mimic the positive effects of calorie restriction on lifespan in Microcebus murinus. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40021720/ · DOI 10.1038/s42003-024-07387-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6d4bf9be-3211-52c8-a826-05f98bcc9f34","evidence_kind":"source_excerpt","locator":"Lines 510-516","start_line":510,"end_line":516,"excerpt":"## resveratrol-lemur-mortality\nA higher sample median is not automatically a demonstrated survival benefit.\nIn the 33-male RESTRIKAL cohort, long-term 200 mg/kg/day resveratrol did not significantly reduce all-cause or age-related mortality despite a higher observed median lifespan.\nModel: 18 resveratrol and 15 controls; lifelong follow-up.\nLimitations: Small male-only nonhuman-primate cohort; earlier reports from this program are not independent samples.\nEvidence access: Primary full text\nResveratrol does not mimic the positive effects of calorie restriction on lifespan in Microcebus murinus. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40021720/ · DOI 10.1038/s42003-024-07387-9","model_system":"18 resveratrol and 15 controls; lifelong follow-up.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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