{"id":"6b277c99-24fb-595a-8426-4e8b7a26bab7","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-nrf2-stability","predicate":"stabilizes","statement":"In the mouse-cell study, fisetin increased Nrf2 stability and Nrf2-dependent transcription.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"9a1f82f3-cb87-5bef-882b-50eb67026976","mechanism_event_label":"Stress-defense transcription can stay active for longer.","subject":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"object":{"id":"95319607-3946-51b3-8235-400ec3223692","slug":"mouse-nfe2l2","display_name":"Mouse Nrf2 / Nfe2l2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"9a1f82f3-cb87-5bef-882b-50eb67026976","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-nrf2-stability-event","event_type":"observed_relationship","label":"Stress-defense transcription can stay active for longer.","description":"In the mouse-cell study, fisetin increased Nrf2 stability and Nrf2-dependent transcription.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"95319607-3946-51b3-8235-400ec3223692","slug":"mouse-nfe2l2","display_name":"Mouse Nrf2 / Nfe2l2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary abstract plus PubMed mouse-protein indexing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No direct Nrf2 binding site or specific KEAP1 reaction established here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Stress-defense transcription can stay active for longer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid fisetin. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23618921/ · DOI 10.1016/j.bcp.2013.04.010","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b39d3f38-aacb-5486-8223-af052fe82121","evidence_kind":"source_excerpt","locator":"Lines 104-110","start_line":104,"end_line":110,"excerpt":"## fisetin-nrf2-stability\nStress-defense transcription can stay active for longer.\nIn the mouse-cell study, fisetin increased Nrf2 stability and Nrf2-dependent transcription.\nModel: Primary abstract plus PubMed mouse-protein indexing.\nLimitations: No direct Nrf2 binding site or specific KEAP1 reaction established here.\nEvidence access: Primary abstract\nConcurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid fisetin. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23618921/ · DOI 10.1016/j.bcp.2013.04.010","model_system":"Primary abstract plus PubMed mouse-protein indexing.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}