{"id":"6b19478a-7e45-5da2-81ad-9a652f16b552","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-hdl-pon1","predicate":"intervention_increased","statement":"Both lycopene intervention routes increased serum and HDL3-associated PON1 activity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"be6451ae-05d3-552e-baab-b86459f0c2b6","mechanism_event_label":"The activity of an enzyme carried by HDL changed.","subject":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"object":{"id":"95a9f64d-c8d8-5e96-8992-1c2ff9273d08","slug":"hdl3-pon1-activity","display_name":"HDL3-associated PON1 activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"be6451ae-05d3-552e-baab-b86459f0c2b6","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-hdl-pon1-event","event_type":"biochemical_relationship","label":"The activity of an enzyme carried by HDL changed.","description":"Both lycopene intervention routes increased serum and HDL3-associated PON1 activity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"176ee7ea-3155-5966-a950-93cd29baa90d","slug":"pon1","display_name":"Human paraoxonase 1 / PON1","entity_type_key":"protein"},"role":"measured_enzyme","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"37362a8d-740c-5822-977c-872c105ab6ee","slug":"lcat","display_name":"Human lecithin-cholesterol acyltransferase / LCAT","entity_type_key":"protein"},"role":"measured_enzyme","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5ee4b23a-5213-57c5-8300-7dd1424a01ca","slug":"cetp","display_name":"Human cholesteryl ester transfer protein / CETP","entity_type_key":"protein"},"role":"measured_transfer_protein","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"95a9f64d-c8d8-5e96-8992-1c2ff9273d08","slug":"hdl3-pon1-activity","display_name":"HDL3-associated PON1 activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/35978954.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ed024b652760ea2f5ab124162690901b3e88995ea9648bea05b59f240de08c3a\", \"start_char\": 0, \"end_char\": 2778, \"text_sha256\": \"ed024b652760ea2f5ab124162690901b3e88995ea9648bea05b59f240de08c3a\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized diet/supplement trial biomarker analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Low tomato control; 224-350 mg/week food lycopene; or 70 mg/week supplement","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Food and supplement doses differ; enzyme activities and particle sizes are surrogate endpoints, not proof of fewer events.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, 225 adults aged 40-65 years","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The activity of an enzyme carried by HDL changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p35978954] Lycopene-rich diets modulate HDL functionality and associated inflammatory markers without affecting lipoprotein size and distribution in moderately overweight, disease-free, middle-aged adults: A randomized controlled trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35978954/ DOI: 10.3389/fnut.2022.954593","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"HDL fractions and plasma lipoproteins","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7ec44729-0b3e-5701-857f-2655416fb8d1","evidence_kind":"source_excerpt","locator":"Lines 1014-1025","start_line":1014,"end_line":1025,"excerpt":"### lycopene-hdl-pon1\nBoth lycopene intervention routes increased serum and HDL3-associated PON1 activity.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The activity of an enzyme carried by HDL changed.\norganism: Human, 225 adults aged 40-65 years\ntissue_or_cell_type: HDL fractions and plasma lipoproteins\nexperimental_model: Randomized diet/supplement trial biomarker analysis\nlimitations: Food and supplement doses differ; enzyme activities and particle sizes are surrogate endpoints, not proof of fewer events.\nexposure: Low tomato control; 224-350 mg/week food lycopene; or 70 mg/week supplement\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/35978954.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ed024b652760ea2f5ab124162690901b3e88995ea9648bea05b59f240de08c3a\", \"start_char\": 0, \"end_char\": 2778, \"text_sha256\": \"ed024b652760ea2f5ab124162690901b3e88995ea9648bea05b59f240de08c3a\"}\n[lycopene-p35978954] Lycopene-rich diets modulate HDL functionality and associated inflammatory markers without affecting lipoprotein size and distribution in moderately overweight, disease-free, middle-aged adults: A randomized controlled trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35978954/ DOI: 10.3389/fnut.2022.954593","model_system":"Randomized diet/supplement trial biomarker analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lycopene-p35978954] Lycopene-rich diets modulate HDL functionality and associated inflammatory markers without affecting lipoprotein size and distribution in moderately overweight, disease-free, middle-aged adults: A randomized controlled trial. 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