{"id":"6af9810b-6bc4-5578-9ab4-d60ebb5aca39","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-renal-elimination","predicate":"eliminated_via","statement":"After intravenous boric acid, urinary recovery over 120 hours was 98.7 ± 9.1% of the dose.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"746fbc5e-a230-5dde-a28a-ae2b3b679925","mechanism_event_label":"The kidneys removed almost all of the administered amount over the collection period.","subject":{"id":"56db2f3c-f247-573f-bb7c-47cac02ea60f","slug":"boric-acid","display_name":"Boric acid / orthoboric acid / B(OH)3","entity_type_key":"small_molecule"},"object":{"id":"5ba7ded0-4d95-5ca2-ab42-da72fefef649","slug":"urinary-boron-excretion","display_name":"Urinary boron excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"746fbc5e-a230-5dde-a28a-ae2b3b679925","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-renal-elimination-event","event_type":"observed_intervention","label":"The kidneys removed almost all of the administered amount over the collection period.","description":"After intravenous boric acid, urinary recovery over 120 hours was 98.7 ± 9.1% of the dose.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"56db2f3c-f247-573f-bb7c-47cac02ea60f","slug":"boric-acid","display_name":"Boric acid / orthoboric acid / B(OH)3","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5ba7ded0-4d95-5ca2-ab42-da72fefef649","slug":"urinary-boron-excretion","display_name":"Urinary boron excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/6732506.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61\", \"start_char\": 0, \"end_char\": 652, \"text_sha256\": \"7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-dose intravenous pharmacokinetics in eight adult men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"562–611 mg boric acid over 20 minutes; plasma followed three days and urine 120 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Historical intravenous experimental exposure is not an oral supplement regimen. These kinetics should not be generalized to kidney impairment or every exposure route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The kidneys removed almost all of the administered amount over the collection period.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p6732506] Boric acid single dose pharmacokinetics after intravenous administration to man. (1984). https://pubmed.ncbi.nlm.nih.gov/6732506/ DOI: 10.1007/bf00316588","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma and urine; six participants included in compartment fitting","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"38520a91-32e3-5d71-b3ca-903fcad61449","evidence_kind":"source_excerpt","locator":"Lines 1093-1104","start_line":1093,"end_line":1104,"excerpt":"### boron-renal-elimination\nAfter intravenous boric acid, urinary recovery over 120 hours was 98.7 ± 9.1% of the dose.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The kidneys removed almost all of the administered amount over the collection period.\norganism: Human\ntissue_or_cell_type: Plasma and urine; six participants included in compartment fitting\nexperimental_model: Single-dose intravenous pharmacokinetics in eight adult men\nlimitations: Historical intravenous experimental exposure is not an oral supplement regimen. These kinetics should not be generalized to kidney impairment or every exposure route.\nexposure: 562–611 mg boric acid over 20 minutes; plasma followed three days and urine 120 hours\nevidence_span: {\"source_cache\": \"artifacts/boron-research/6732506.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61\", \"start_char\": 0, \"end_char\": 652, \"text_sha256\": \"7deee2df94fd1ab9d173e7ddf97660bd8402d51bed8ac2bb8cac8810be66ca61\"}\n[boron-p6732506] Boric acid single dose pharmacokinetics after intravenous administration to man. (1984). https://pubmed.ncbi.nlm.nih.gov/6732506/ DOI: 10.1007/bf00316588","model_system":"Single-dose intravenous pharmacokinetics in eight adult men","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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