{"id":"6aef58e1-8184-5b5c-a13f-b334a741216d","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-zinc-improves-retinol-marker","predicate":"supplementation_increases","statement":"Zinc increased plasma retinol and transthyretin versus placebo; the RBP increase was not significant.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c63a42c7-1889-5000-b16b-71109eb842d1","mechanism_event_label":"Zinc status can influence vitamin A transport-related blood measurements.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"3d7326b1-abb8-5957-bc1b-9c7c9c98063b","slug":"plasma-retinol-concentration","display_name":"Plasma retinol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c63a42c7-1889-5000-b16b-71109eb842d1","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-zinc-improves-retinol-marker-event","event_type":"observed_intervention","label":"Zinc status can influence vitamin A transport-related blood measurements.","description":"Zinc increased plasma retinol and transthyretin versus placebo; 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the RBP increase was not significant.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Zinc status can influence vitamin A transport-related blood measurements.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: Six-month preschool trial.\nlimitations: No direct proof of restored liver release or increased RBP synthesis.\ncross_nutrient: Zinc -> vitamin A biomarkers.\n[va-munoz2000] Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers (2000). https://pubmed.ncbi.nlm.nih.gov/10702174/ DOI: 10.1093/ajcn/71.3.789","model_system":"Six-month preschool trial.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [va-munoz2000] Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers (2000). https://pubmed.ncbi.nlm.nih.gov/10702174/ DOI: 10.1093/ajcn/71.3.789","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}