{"id":"6ae1e920-2b39-56f3-9c31-2fef52619f65","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-dangour-status-response","predicate":"supplementation_improved_circulating_status","statement":"Cyanocobalamin increased serum B12 and holotranscobalamin and reduced total homocysteine during the 12-month trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"c5e9c8b3-efcc-500e-aef1-f594be10f725","mechanism_event_label":"The tablets changed the biochemical measurements.","subject":{"id":"4cb4dfbc-6cd9-5bd5-98dc-d0a8fb6cfee4","slug":"cyanocobalamin","display_name":"Cyanocobalamin","entity_type_key":"small_molecule"},"object":{"id":"8390898f-7915-5c30-8ada-c416a386f5f3","slug":"serum-cobalamin-concentration","display_name":"Serum cobalamin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c5e9c8b3-efcc-500e-aef1-f594be10f725","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-dangour-status-response-event","event_type":"observed_intervention","label":"The tablets changed the biochemical measurements.","description":"Cyanocobalamin increased serum B12 and holotranscobalamin and reduced total homocysteine during the 12-month trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6e4b60d-5e8a-512b-b5f4-7c25ae0fda9a","slug":"holotranscobalamin-concentration","display_name":"Circulating holotranscobalamin concentration","entity_type_key":"cellular_process"},"role":"measured_marker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"role":"measured_marker","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4cb4dfbc-6cd9-5bd5-98dc-d0a8fb6cfee4","slug":"cyanocobalamin","display_name":"Cyanocobalamin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8390898f-7915-5c30-8ada-c416a386f5f3","slug":"serum-cobalamin-concentration","display_name":"Serum cobalamin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [b12-dangour2015] Effects of vitamin B-12 supplementation on neurologic and cognitive function in older people: a randomized controlled trial (2015). https://pubmed.ncbi.nlm.nih.gov/26135351/ DOI: 10.3945/ajcn.115.110775","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73145023-2982-5848-aff2-8d8875d6b9c5","stable_key":"import-7fc92b9e-9cbf-556e-8719-6b5244625250","title":"Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ad5b3a51d36e856aa7fdfd1cc23f690b094689bad87d28e1a621a54675a01c92","revision_id":"118bd616-0c13-549f-bfeb-bc439715b89c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}