{"id":"6a214e7a-007e-5853-bc08-6c061111071b","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-mri-whole-cohort","predicate":"does_not_significantly_change_tested","statement":"In ten men, 60-minute gastric residual volume did not differ significantly between mixed liquid meals with and without 0.5% MSG, P=0.45.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"5c79a6b1-c7b1-5cc4-bf2f-13e08f0db54b","mechanism_event_label":"The whole-cohort test must stay visible.","subject":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"object":{"id":"a1d82706-07ba-59cd-a1b4-1f22c3a787b9","slug":"human-msg-mri-gastric-residual","display_name":"Human gastric residual volume in MSG MRI study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5c79a6b1-c7b1-5cc4-bf2f-13e08f0db54b","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-mri-whole-cohort-event","event_type":"observed_relationship","label":"The whole-cohort test must stay visible.","description":"In ten men, 60-minute gastric residual volume did not differ significantly between mixed liquid meals with and without 0.5% MSG, P=0.45.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a1d82706-07ba-59cd-a1b4-1f22c3a787b9","slug":"human-msg-mri-gastric-residual","display_name":"Human gastric residual volume in MSG MRI study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text; results","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"200 kcal/200 mL meal; serial MRI.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different meal and measurement from the breath-test study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The whole-cohort test must stay visible.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Gastric emptying and duodenal motility upon intake of a liquid meal with monosodium glutamate in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24744869/ · DOI 10.1002/phy2.187","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"59ba407d-caa6-5da1-9172-92df16d3578c","evidence_kind":"source_excerpt","locator":"Lines 234-240","start_line":234,"end_line":240,"excerpt":"## monosodium-glutamate-mri-whole-cohort\nThe whole-cohort test must stay visible.\nIn ten men, 60-minute gastric residual volume did not differ significantly between mixed liquid meals with and without 0.5% MSG, P=0.45.\nModel: 200 kcal/200 mL meal; serial MRI.\nLimitations: Different meal and measurement from the breath-test study.\nEvidence access: Primary full text; results\nGastric emptying and duodenal motility upon intake of a liquid meal with monosodium glutamate in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24744869/ · DOI 10.1002/phy2.187","model_system":"200 kcal/200 mL meal; serial MRI.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"90a81fe5-8622-52f6-b4db-04899206c2b0","stable_key":"import-561b2b40-5b59-548f-a749-f357f7e2304c","title":"Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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