{"id":"6a134170-a529-5035-a9c3-038646652ce3","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-cpt1-oxidation","predicate":"reduces","statement":"Four weeks of astaxanthin feeding reduced exercise-associated oxidative modification of CPT I and increased FAT/CD36-CPT I colocalization in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8c927637-cad3-50d2-a05b-8a87d299d896","mechanism_event_label":"A fat-transport pathway was less oxidatively modified during exercise.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"7aff5d66-2b6b-5120-a204-5d638c523b4d","slug":"mouse-astaxanthin-cpt1-oxidation","display_name":"Exercise-associated oxidative modification of mouse CPT I","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8c927637-cad3-50d2-a05b-8a87d299d896","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-cpt1-oxidation-event","event_type":"observed_relationship","label":"A fat-transport pathway was less oxidatively modified during exercise.","description":"Four weeks of astaxanthin feeding reduced exercise-associated oxidative modification of CPT I and increased FAT/CD36-CPT I colocalization in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7aff5d66-2b6b-5120-a204-5d638c523b4d","slug":"mouse-astaxanthin-cpt1-oxidation","display_name":"Exercise-associated oxidative modification of mouse CPT I","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6e9b840a-34c2-5147-90fb-43cb1c6844c5","slug":"mouse-cpt1-family","display_name":"Mouse carnitine palmitoyltransferase I; isoform unresolved","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"98f1fe60-4f89-5d3f-830a-d1f61988a90c","slug":"mouse-cd36","display_name":"Mouse fatty-acid translocase / Cd36","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"ICR mice and treadmill exercise; protein modification and localization measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"CPT I isoform was not resolved in the accessed abstract; astaxanthin is not a demonstrated CPT cofactor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A fat-transport pathway was less oxidatively modified during exercise.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18082622/ · DOI 10.1016/j.bbrc.2007.12.019","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3c769f8b-38fa-503f-bcaa-ca692652d3a5","evidence_kind":"source_excerpt","locator":"Lines 342-348","start_line":342,"end_line":348,"excerpt":"## astaxanthin-cpt1-oxidation\nA fat-transport pathway was less oxidatively modified during exercise.\nFour weeks of astaxanthin feeding reduced exercise-associated oxidative modification of CPT I and increased FAT/CD36-CPT I colocalization in mice.\nModel: ICR mice and treadmill exercise; protein modification and localization measurements.\nLimitations: CPT I isoform was not resolved in the accessed abstract; astaxanthin is not a demonstrated CPT cofactor.\nEvidence access: Primary abstract\nAstaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18082622/ · DOI 10.1016/j.bbrc.2007.12.019","model_system":"ICR mice and treadmill exercise; protein modification and localization measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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