{"id":"69c08955-1801-5409-ba81-ab54c31a2ae9","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-mouse-plus-maze","predicate":"increases_in_recorded_comparison","statement":"The earlier mouse experiment reported anxiolytic-like plus-maze behavior without the tested anticonvulsant or muscle-relaxant effects; a tenfold larger dose caused mild sedation.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"6b405a88-9df2-5a30-be0d-10710c878cf9","mechanism_event_label":"The earlier mouse experiment reported anxiolytic-like plus-maze behavior without the tested anticonvulsant or muscle-relaxant effects; a tenfold larger dose caused mild sedation.","subject":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"object":{"id":"a40b0e7d-d0f5-5867-9026-91f7d7381c81","slug":"api-mouse-plus-maze","display_name":"Mouse elevated-plus-maze behavior with apigenin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6b405a88-9df2-5a30-be0d-10710c878cf9","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-mouse-plus-maze-event","event_type":"experimental_observation","label":"The earlier mouse experiment reported anxiolytic-like plus-maze behavior without the tested anticonvulsant or muscle-relaxant effects; a tenfold larger dose caused mild sedation.","description":"### api-mouse-plus-maze\n\nThe earlier mouse experiment reported anxiolytic-like plus-maze behavior without the tested anticonvulsant or muscle-relaxant effects; a tenfold larger dose caused mild sedation.\nBehavioral assay labels do not establish a human anxiety indication or subtype-selective GABA pharmacology.\nModel and exposure: Mouse behavior accompanying the 1995 binding study.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. | 1995 | https://pubmed.ncbi.nlm.nih.gov/7617761/ | https://doi.org/10.1055/s-2006-958058 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"Apigenin","sequence_order":0,"notes":""},{"entity":{"id":"a40b0e7d-d0f5-5867-9026-91f7d7381c81","slug":"api-mouse-plus-maze","display_name":"Mouse elevated-plus-maze behavior with apigenin","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Apigenin\", \"comparator\": \"Vehicle\", \"endpoint\": \"The earlier mouse experiment reported anxiolytic-like plus-maze behavior without the tested anticonvulsant or muscle-relaxant effects; a tenfold larger dose caused mild sedation.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"Mouse behavior accompanying the 1995 binding study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The earlier mouse experiment reported anxiolytic-like plus-maze behavior without the tested anticonvulsant or muscle-relaxant effects; a tenfold larger dose caused mild sedation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. | https://pubmed.ncbi.nlm.nih.gov/7617761/ | https://doi.org/10.1055/s-2006-958058","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-mouse-plus-maze; Behavioral assay labels do not establish a human anxiety indication or subtype-selective GABA pharmacology.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1d9b0199-9173-5ea6-874c-2a61f168ba8a","evidence_kind":"source_excerpt","locator":"Lines 804-810","start_line":804,"end_line":810,"excerpt":"### api-mouse-plus-maze\n\nThe earlier mouse experiment reported anxiolytic-like plus-maze behavior without the tested anticonvulsant or muscle-relaxant effects; a tenfold larger dose caused mild sedation.\nBehavioral assay labels do not establish a human anxiety indication or subtype-selective GABA pharmacology.\nModel and exposure: Mouse behavior accompanying the 1995 binding study.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. | 1995 | https://pubmed.ncbi.nlm.nih.gov/7617761/ | https://doi.org/10.1055/s-2006-958058 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Mouse behavior accompanying the 1995 binding study.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}