{"id":"69ae1391-bbb2-5b5d-af36-7b61825018eb","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-liver-supply-rescue","predicate":"when_synthesized_in_liver_reverses","statement":"Engineering threonine biosynthetic capacity selectively in hepatocytes reversed the systemic response to dietary threonine restriction.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"149b707d-1512-51fd-801d-f43c971c8867","mechanism_event_label":"Restoring supply in one organ changed a whole-body nutritional signal.","subject":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"object":{"id":"c2efb5e5-3604-5db1-ae26-381bbbbd372e","slug":"mouse-threonine-fgf21-remodeling","display_name":"Mouse threonine-restriction metabolic remodeling","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"149b707d-1512-51fd-801d-f43c971c8867","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-liver-supply-rescue-event","event_type":"observed_relationship","label":"Restoring supply in one organ changed a whole-body nutritional signal.","description":"Engineering threonine biosynthetic capacity selectively in hepatocytes reversed the systemic response to dietary threonine restriction.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c2efb5e5-3604-5db1-ae26-381bbbbd372e","slug":"mouse-threonine-fgf21-remodeling","display_name":"Mouse threonine-restriction metabolic remodeling","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8b01fe3c-a32b-5076-9c61-34d4d35e8b89","slug":"mouse-fgf21","display_name":"Mouse fibroblast growth factor 21 / Fgf21","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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