{"id":"69ad5926-2138-5431-a503-1a551529b6db","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-dopaminergic-atp","predicate":"preserves","statement":"Ergothioneine limited ATP loss, protein carbonylation and tyrosine hydroxylase loss in the human 6-OHDA cell experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"602450cc-ee8f-5c50-b5fd-2056447911ce","mechanism_event_label":"Protection involved energy and dopamine-related cell markers.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"df7eb08f-a4be-5a76-96ab-d6f76a72e74a","slug":"human-dopaminergic-cell-atp","display_name":"Human dopaminergic-cell ATP content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"602450cc-ee8f-5c50-b5fd-2056447911ce","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-dopaminergic-atp-event","event_type":"observed_relationship","label":"Protection involved energy and dopamine-related cell markers.","description":"Ergothioneine limited ATP loss, protein carbonylation and tyrosine hydroxylase loss in the human 6-OHDA cell experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"df7eb08f-a4be-5a76-96ab-d6f76a72e74a","slug":"human-dopaminergic-cell-atp","display_name":"Human dopaminergic-cell ATP content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"58b974f1-d389-5bf6-81cd-889c44442c42","slug":"atp","display_name":"ATP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e4e0f24b-1e70-573d-b719-039a90191b90","slug":"human-tyrosine-hydroxylase","display_name":"Human tyrosine hydroxylase","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human iPSC-derived neurons and neuroblastoma cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"These correlated outcomes do not identify a single direct mitochondrial target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Protection involved energy and dopamine-related cell markers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ergothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38929132/ · DOI 10.3390/antiox13060693","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8874676b-2ece-5dbd-b4d8-561499d700d1","evidence_kind":"source_excerpt","locator":"Lines 392-398","start_line":392,"end_line":398,"excerpt":"## ergothioneine-dopaminergic-atp\nProtection involved energy and dopamine-related cell markers.\nErgothioneine limited ATP loss, protein carbonylation and tyrosine hydroxylase loss in the human 6-OHDA cell experiments.\nModel: Human iPSC-derived neurons and neuroblastoma cells.\nLimitations: These correlated outcomes do not identify a single direct mitochondrial target.\nEvidence access: Primary abstract\nErgothioneine-Mediated Neuroprotection of Human iPSC-Derived Dopaminergic Neurons. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38929132/ · DOI 10.3390/antiox13060693","model_system":"Human iPSC-derived neurons and neuroblastoma cells.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}