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(2006). https://pubmed.ncbi.nlm.nih.gov/16511496/ DOI: 10.1038/nature04512","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Developing erythroblasts and mitochondria","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5fd4f133-d986-5ba0-90f3-ba142c2d8ee1","evidence_kind":"source_excerpt","locator":"Lines 459-470","start_line":459,"end_line":470,"excerpt":"### iron-mitoferrin-import\nMitoferrin function was required for mitochondrial iron assimilation and heme synthesis in the tested vertebrate erythroblasts.\nCondition category: normal\nnutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The final iron delivery step for heme synthesis is across the mitochondrial membrane.\norganism: Zebrafish, mice and yeast\ntissue_or_cell_type: Developing erythroblasts and mitochondria\nexperimental_model: Zebrafish mutant, mouse stem-cell knockout and cross-species rescue\nlimitations: Species-specific loss/rescue evidence; no claim that plasma iron alone measures mitochondrial iron delivery.\nexposure: Mitoferrin loss and rescue\nevidence_span: {\"source_cache\": \"artifacts/iron-research/16511496.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"cb2b06715c001133d1f1173d5084a2689170fa9a0e14f3b7b0a0cb5a7b6a5234\", \"start_char\": 0, \"end_char\": 1533, \"text_sha256\": \"cb2b06715c001133d1f1173d5084a2689170fa9a0e14f3b7b0a0cb5a7b6a5234\"}\n[iron-p16511496] Mitoferrin is essential for erythroid iron assimilation. 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