{"id":"693f9bfb-5d10-55be-b6f9-353d51a16c22","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-erinacine-c-trka","predicate":"promotes_via","statement":"Erinacine C induced PC12 differentiation through TrkA and associated PLC-gamma, PI3K and ERK pathways.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a7cb43ff-9d2f-5ec3-bc2f-83fbeaf8a228","mechanism_event_label":"Erinacine C induced PC12 differentiation through TrkA and associated PLC-gamma, PI3K and ERK pathways.","subject":{"id":"5f9b1918-609a-536a-80db-b6ccb39688f4","slug":"erinacine-c","display_name":"Erinacine C","entity_type_key":"small_molecule"},"object":{"id":"0b6cb944-25ae-55f7-8a23-78bc545f3195","slug":"trka-dependent-pc12-differentiation","display_name":"TrkA-dependent PC12 differentiation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a7cb43ff-9d2f-5ec3-bc2f-83fbeaf8a228","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-erinacine-c-trka-event","event_type":"observed_relationship","label":"Erinacine C induced PC12 differentiation through TrkA and associated PLC-gamma, PI3K and ERK pathways.","description":"Erinacine C induced PC12 differentiation through TrkA and associated PLC-gamma, PI3K and ERK pathways.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5f9b1918-609a-536a-80db-b6ccb39688f4","slug":"erinacine-c","display_name":"Erinacine C","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0b6cb944-25ae-55f7-8a23-78bc545f3195","slug":"trka-dependent-pc12-differentiation","display_name":"TrkA-dependent PC12 differentiation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ff1c9e4e-79c5-58c8-8a67-d98b227b5313","slug":"trka","display_name":"Tropomyosin receptor kinase A / NTRK1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"359979da-c958-50bf-b2f7-9f15e177fa5d","slug":"pi3k-family","display_name":"Phosphoinositide 3-kinase family","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"2944ff54-7d74-5b34-bc0c-c77ac1444717","slug":"erk1-2","display_name":"ERK1/2 proteins, isoform not resolved","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Erinacine C with genetic and pharmacological inhibitors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Differentiation assay","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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