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The functional claim rests on channel activation in transfected cells rather than in native tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gaba","display_name":"Gamma-aminobutyric acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat and human genes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Two proteins that each do almost nothing on their own make a working receptor only when put together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[gb-p9872315] GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. 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The functional claim rests on channel activation in transfected cells rather than in native tissue.\nexposure: GABA-B R1 and R2 expressed alone and together, with GIRK-type potassium channel activity as the readout\nevidence_span: {\"source_cache\": \"artifacts/gaba-research/9872315.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c6687fd9eb8b7ebcc0496a2385b0201b02662a5fe8da87a0089650a150f00613\", \"start_char\": 0, \"end_char\": 1473, \"text_sha256\": \"c6687fd9eb8b7ebcc0496a2385b0201b02662a5fe8da87a0089650a150f00613\"}\n[gb-p9872315] GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. 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