{"id":"6907cc5d-0abb-5cf5-ac2c-7752a52bae45","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-octn2-acetyl","predicate":"transports","statement":"Expressed human OCTN2 transported acetyl-L-carnitine in a sodium-dependent manner with a measured Km of 8.5 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8697bdeb-0c14-5ea4-807b-93283febb486","mechanism_event_label":"The transporter also carries the acetylated form.","subject":{"id":"fb9ae9da-e4d3-5557-baac-d8b00e98ba10","slug":"slc22a5","display_name":"Human carnitine transporter OCTN2 / SLC22A5","entity_type_key":"protein"},"object":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"8697bdeb-0c14-5ea4-807b-93283febb486","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-octn2-acetyl-event","event_type":"observed_relationship","label":"The transporter also carries the acetylated form.","description":"Expressed human OCTN2 transported acetyl-L-carnitine in a sodium-dependent manner with a measured Km of 8.5 micromolar.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fb9ae9da-e4d3-5557-baac-d8b00e98ba10","slug":"slc22a5","display_name":"Human carnitine transporter OCTN2 / SLC22A5","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human OCTN2 in HEK293 cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A kinetic constant is not a treatment target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The transporter also carries the acetylated form.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10525100/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Sodium-dependent acetylcarnitine transport with a measured Km of 8.5 micromolar.","entity":null},{"dimension":"transport_pool","value_text":"the expressing cell","comparator":null,"unit":null,"notes":"Sodium-dependent acetylcarnitine transport with a measured Km of 8.5 micromolar.","entity":null}],"evidence":[{"id":"a5211aed-6aa9-5262-a196-806216b18eb6","evidence_kind":"source_excerpt","locator":"Lines 50-56","start_line":50,"end_line":56,"excerpt":"## l-carnitine-octn2-acetyl\nThe transporter also carries the acetylated form.\nExpressed human OCTN2 transported acetyl-L-carnitine in a sodium-dependent manner with a measured Km of 8.5 micromolar.\nModel: Human OCTN2 in HEK293 cells.\nLimitations: A kinetic constant is not a treatment target.\nEvidence access: Primary abstract\nNa(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10525100/","model_system":"Human OCTN2 in HEK293 cells.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2c9c42b-806a-55e2-abde-b0320ea94704","stable_key":"import-6cdb37aa-8998-5ea8-829d-4f995caf98fc","title":"L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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