{"id":"68d15992-dad4-5ca4-af32-3c3a06c8ae6f","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-statin-muscle-low","predicate":"reduces_in_trial","statement":"Muscle CoQ fell from 39.7 to 26.4 nmol/g with simvastatin 80 mg/day; it did not fall with atorvastatin 40 mg/day or placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5bd97196-da8f-5a2e-9418-2c626715908c","mechanism_event_label":"Some regimens lowered the muscle pool, but the finding did not apply equally to every statin arm.","subject":{"id":"b7de977d-fed9-5b1c-8138-fd951442b067","slug":"simvastatin","display_name":"Simvastatin","entity_type_key":"small_molecule"},"object":{"id":"9c185815-74b8-5542-b236-f302b620c1e8","slug":"coq-muscle-concentration","display_name":"Muscle coenzyme Q10 concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5bd97196-da8f-5a2e-9418-2c626715908c","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-statin-muscle-low-event","event_type":"observed_intervention","label":"Some regimens lowered the muscle pool, but the finding did not apply equally to every statin arm.","description":"Muscle CoQ fell from 39.7 to 26.4 nmol/g with simvastatin 80 mg/day; it did not fall with atorvastatin 40 mg/day or placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"64f4b2c7-afdf-5b9a-b6f9-015a7aa96eee","slug":"atorvastatin","display_name":"Atorvastatin","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b7de977d-fed9-5b1c-8138-fd951442b067","slug":"simvastatin","display_name":"Simvastatin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9c185815-74b8-5542-b236-f302b620c1e8","slug":"coq-muscle-concentration","display_name":"Muscle coenzyme Q10 concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/16003294.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6293a60171af6eb5cc8dc58449792c024ee282cdbcb80f777dc9156f4c44250b\", \"start_char\": 0, \"end_char\": 1774, \"text_sha256\": \"6293a60171af6eb5cc8dc58449792c024ee282cdbcb80f777dc9156f4c44250b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial with muscle biopsies","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Simvastatin 80 mg/day, atorvastatin 40 mg/day or placebo for eight weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different statin/dose regimens. 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Respiratory-enzyme comparison selected six simvastatin participants with marked CoQ decline and matched participants; not an unbiased whole-arm estimate.\nexposure: Simvastatin 80 mg/day, atorvastatin 40 mg/day or placebo for eight weeks\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/16003294.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6293a60171af6eb5cc8dc58449792c024ee282cdbcb80f777dc9156f4c44250b\", \"start_char\": 0, \"end_char\": 1774, \"text_sha256\": \"6293a60171af6eb5cc8dc58449792c024ee282cdbcb80f777dc9156f4c44250b\"}\n[coq10-p16003294] High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial. 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