{"id":"68a98899-fe3b-5335-9942-10c27434c75c","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-matsuda","predicate":"reduces","statement":"Sucrose beverages reduced Matsuda insulin sensitivity compared with aspartame in the matched-group intervention.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"63c36ff4-da40-5a21-bda0-6c3838ffac15","mechanism_event_label":"Sucrose beverages reduced Matsuda insulin sensitivity compared with aspartame in the matched-group intervention.","subject":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"object":{"id":"e0f8ea3d-6b7f-5bea-88fd-46f624947c6a","slug":"human-matsuda-insulin-sensitivity","display_name":"Human Matsuda insulin sensitivity index","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"63c36ff4-da40-5a21-bda0-6c3838ffac15","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-matsuda-event","event_type":"observed_relationship","label":"Sucrose beverages reduced Matsuda insulin sensitivity compared with aspartame in the matched-group intervention.","description":"Sucrose beverages reduced Matsuda insulin sensitivity compared with aspartame in the matched-group intervention.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e0f8ea3d-6b7f-5bea-88fd-46f624947c6a","slug":"human-matsuda-insulin-sensitivity","display_name":"Human Matsuda insulin sensitivity index","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Sucrose or HFCS beverages at 25% of energy requirement versus aspartame, 3 servings/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"16 days, approximately two weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results and metadata inspected.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"75 adults in nonrandomized double-blind matched groups; sucrose n=24, HFCS n=28, aspartame n=23","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Direct sucrose beverage comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Nonrandomized; paired MRI n=23 sucrose, 23 HFCS, 20 control. Outpatient calories not clamped; weight adjustment does not establish calorie independence. HFCS/control participants and some plasma outcomes overlap PMID 25904601. Short biomarkers are not clinical disease incidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"75 adults in nonrandomized double-blind matched groups; sucrose n=24, HFCS n=28, aspartame n=23","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Sucrose beverages reduced Matsuda insulin sensitivity compared with aspartame in the matched-group intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults. (2021). https://pubmed.ncbi.nlm.nih.gov/34265055/ DOI: 10.1210/clinem/dgab508","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral beverages; outpatient usual diet, controlled inpatient meal substitutions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"MRI liver fat, OGTT-derived insulin sensitivity and plasma markers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8b76b98c-7289-5d27-a97e-2a087a10ce3d","evidence_kind":"source_excerpt","locator":"Lines 343-353","start_line":343,"end_line":353,"excerpt":"## sucrose-matsuda\nSucrose beverages reduced Matsuda insulin sensitivity compared with aspartame in the matched-group intervention.\nModel/species: 75 adults in nonrandomized double-blind matched groups; sucrose n=24, HFCS n=28, aspartame n=23\nTissue: MRI liver fat, OGTT-derived insulin sensitivity and plasma markers\nExposure: Sucrose or HFCS beverages at 25% of energy requirement versus aspartame, 3 servings/day\nRoute: Oral beverages; outpatient usual diet, controlled inpatient meal substitutions\nDuration: 16 days, approximately two weeks\nExposure scope: Direct sucrose beverage comparison\nLimits: Nonrandomized; paired MRI n=23 sucrose, 23 HFCS, 20 control. Outpatient calories not clamped; weight adjustment does not establish calorie independence. HFCS/control participants and some plasma outcomes overlap PMID 25904601. Short biomarkers are not clinical disease incidence.\nReference: Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults. (2021). https://pubmed.ncbi.nlm.nih.gov/34265055/ DOI: 10.1210/clinem/dgab508\nAccess: Primary full-text methods/results and metadata inspected.","model_system":"75 adults in nonrandomized double-blind matched groups; sucrose n=24, HFCS n=28, aspartame n=23","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8e24ddf4-84ee-57b4-9fd8-093547432ece","stable_key":"import-c932089b-ebc9-5f39-b2e5-84af74f9f6d0","title":"Sucrose: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text.","file_path":"","sha256":"5e68ccbade7a80fc03778495756f0eeeeba5038cd10d5bef8e33cb1e93e4b044","revision_id":"6edb8ffc-11c5-5cd9-852c-85adb71165a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}