{"id":"68a88e53-468e-5253-9951-b96925a23de5","stable_key":"a2968a2f-5b00-5212-8b8c-8a4262bcb149:tet2-mutation-in-lymphoid-disorders","predicate":"is_mutated_in","statement":"TET2 mutations were observed in human lymphoid disorders and could be detected in immature progenitors that retained myeloid colony-forming potential.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"919cebe3-8ff4-5269-b6fe-280dc7f6514a","mechanism_event_label":"TET2 mutations were observed in human lymphoid disorders and could be detected in immature progenitors that retained myeloid colony-forming potential.","subject":{"id":"5433ea92-f679-5b25-a872-cb8a636ae4e1","slug":"tet2-human","display_name":"Human TET2","entity_type_key":"protein"},"object":{"id":"43490a34-f948-5fe1-ae97-c28237bb1cf3","slug":"human-lymphoid-neoplasm-tet2-mutation","display_name":"TET2 mutation in human lymphoid neoplasms","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"919cebe3-8ff4-5269-b6fe-280dc7f6514a","stable_key":"a2968a2f-5b00-5212-8b8c-8a4262bcb149:tet2-mutation-in-lymphoid-disorders-event","event_type":"observed_relationship","label":"TET2 mutations were observed in human lymphoid disorders and could be detected in immature progenitors that retained myeloid colony-forming potential.","description":"The same damaged gene also turns up in lymphoid cancers, not only myeloid ones.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5433ea92-f679-5b25-a872-cb8a636ae4e1","slug":"tet2-human","display_name":"Human TET2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"43490a34-f948-5fe1-ae97-c28237bb1cf3","slug":"human-lymphoid-neoplasm-tet2-mutation","display_name":"TET2 mutation in human lymphoid neoplasms","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Cross-sectional","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human lymphoid disorder samples with progenitor colony assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"No intervention; observational sequencing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Detection in a progenitor shows where the mutation sits in the hierarchy, not that it caused the lymphoid tumour.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same damaged gene also turns up in lymphoid cancers, not only myeloid ones.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[quivoron-2011] TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis (2011). https://pubmed.ncbi.nlm.nih.gov/21723201/ DOI: 10.1016/j.ccr.2011.06.003","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Lymphoid tumour cells and immature progenitors","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1be7dfd0-5777-5fa6-93c3-2f07851c1266","evidence_kind":"source_excerpt","locator":"Lines 83-91","start_line":83,"end_line":91,"excerpt":"## tet2-mutation-in-lymphoid-disorders\nTET2 mutations were observed in human lymphoid disorders and could be detected in immature progenitors that retained myeloid colony-forming potential.\nModel/species: Human lymphoid disorder samples with progenitor colony assays\nOrganism: Homo sapiens\nTissue/system: Lymphoid tumour cells and immature progenitors\nExposure: No intervention; observational sequencing\nDuration: Cross-sectional\nLimits: Detection in a progenitor shows where the mutation sits in the hierarchy, not that it caused the lymphoid tumour.\nPrimary reference: [quivoron-2011] TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis (2011). https://pubmed.ncbi.nlm.nih.gov/21723201/ DOI: 10.1016/j.ccr.2011.06.003","model_system":"Human lymphoid disorder samples with progenitor colony assays","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c0b9b176-985b-55c7-b8f5-f3ca16a7ddfe","stable_key":"import-a2968a2f-5b00-5212-8b8c-8a4262bcb149","title":"TET2 loss and malignancy: the step between a nutrient-responsive enzyme and the disease (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies located by Europe PMC title search, with every statement drafted from the retrieved abstract. Two pairs share a laboratory and are recorded as one line of evidence each. Genetic loss of function, pharmacological exposure and dietary depletion are kept as separate record types. Not publisher full text.","file_path":"","sha256":"22e2c8388d4f0c1813546ba6a9ccee3fa14c0c8f578bd9bd80103c1390b2536b","revision_id":"fbc29d8d-0420-562c-bfdb-1b5af42f2d08","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}