{"id":"6857dd37-6537-5253-853d-67fcf8e95f80","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-deficiency-renal-electrolyte-loss","predicate":"deficiency_associated_with","statement":"Two leukemia cases with acute thiamine deficiency showed proximal tubular dysfunction and electrolyte abnormalities resembling refeeding syndrome.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"14c7af92-ea4a-54ea-96a2-e28686222391","mechanism_event_label":"B1 shortage may accompany kidney losses, which differ from minerals simply moving into cells.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"7867f624-5e41-545f-9a2b-9d1b4f58ce78","slug":"renal-tubular-electrolyte-loss","display_name":"Renal tubular electrolyte loss","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"14c7af92-ea4a-54ea-96a2-e28686222391","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-deficiency-renal-electrolyte-loss-event","event_type":"observed_intervention","label":"B1 shortage may accompany kidney losses, which differ from minerals simply moving into cells.","description":"Two leukemia cases with acute thiamine deficiency showed proximal tubular dysfunction and electrolyte abnormalities resembling refeeding syndrome.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3af495a2-51d2-59ff-be54-a11c13d40acb","slug":"proximal-renal-tubular-function","display_name":"Proximal renal tubular function","entity_type_key":"cellular_process"},"role":"affected_function","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ee63fe8e-92f3-552f-8049-a5f1fa1e1523","slug":"phosphate-ion","display_name":"Inorganic phosphate (Pi; 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no regimen inferred beyond the accessed evidence.\n[b1-maiorana2014] Acute thiamine deficiency and refeeding syndrome: Similar findings but different pathogenesis (2014). https://pubmed.ncbi.nlm.nih.gov/24985016/ DOI: 10.1016/j.nut.2014.02.019","model_system":"Two pediatric cases.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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