{"id":"6827ba68-7c4b-53c9-a2de-a159726e77ee","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-s-oxidation","predicate":"forms_detected_metabolite","statement":"SAC sulfoxide was identified among metabolites after SAC administration to rats and dogs.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5c33997f-41b9-54e4-aa10-875e90e53319","mechanism_event_label":"Oxidation creates another chemically distinct species.","subject":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"object":{"id":"bfb29221-0b4c-5d38-91d2-6a1e3b3b1a62","slug":"s-allylcysteine-sulfoxide","display_name":"S-allyl-L-cysteine sulfoxide, stereoisomer unspecified","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"5c33997f-41b9-54e4-aa10-875e90e53319","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-s-oxidation-event","event_type":"observed_relationship","label":"Oxidation creates another chemically distinct species.","description":"SAC sulfoxide was identified among metabolites after SAC administration to rats and dogs.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bfb29221-0b4c-5d38-91d2-6a1e3b3b1a62","slug":"s-allylcysteine-sulfoxide","display_name":"S-allyl-L-cysteine sulfoxide, stereoisomer unspecified","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f592645c-77f9-59af-b241-96fc60d07b94","slug":"n-acetyl-s-allylcysteine-sulfoxide","display_name":"N-acetyl-S-allyl-L-cysteine sulfoxide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"acting_entity","value_text":"s-allylcysteine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"Rats 5 mg/kg; dogs 2 mg/kg","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Single administration","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_comparison","value_text":"Purified SAC or N-acetyl-SAC; corresponding pharmacokinetic comparisons","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Oral/i.v. pharmacokinetics; liver and kidney S9 experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived research curation; not independent primary verification","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Sulfoxide stereochemistry and responsible enzyme were not resolved in the accessed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"S-allylcysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat and dog","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Oxidation creates another chemically distinct species.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[25681129] Metabolism, excretion, and pharmacokinetics of S-allyl-L-cysteine in rats and dogs. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25681129/ · DOI 10.1124/dmd.115.063230","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral or intravenous; S9 incubation separately","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Oral/i.v. pharmacokinetics; liver and kidney S9 experiments","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f36be380-a44d-5e38-8b53-6a4c61e0450d","evidence_kind":"source_excerpt","locator":"Lines 32-39","start_line":32,"end_line":39,"excerpt":"## s-allylcysteine-s-oxidation\nOxidation creates another chemically distinct species.\nSAC sulfoxide was identified among metabolites after SAC administration to rats and dogs.\nModel: Oral/i.v. pharmacokinetics; liver and kidney S9 experiments\nLimitations: Sulfoxide stereochemistry and responsible enzyme were not resolved in the accessed abstract.\nEvidence access: Primary abstract\n[25681129] Metabolism, excretion, and pharmacokinetics of S-allyl-L-cysteine in rats and dogs. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25681129/ · DOI 10.1124/dmd.115.063230\nStructured context: {\"organism\": \"Rat and dog\", \"tissue_or_cell_type\": \"Oral/i.v. pharmacokinetics; liver and kidney S9 experiments\", \"dose\": \"Rats 5 mg/kg; dogs 2 mg/kg\", \"duration\": \"Single administration\", \"route\": \"Oral or intravenous; S9 incubation separately\", \"experimental_comparison\": \"Purified SAC or N-acetyl-SAC; corresponding pharmacokinetic comparisons\", \"acting_entity\": \"s-allylcysteine\", \"interpretation_status\": \"Source-derived research curation; not independent primary verification\"}","model_system":"Oral/i.v. pharmacokinetics; liver and kidney S9 experiments","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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