{"id":"682096b0-531a-50fd-a286-9bd41976b624","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-abcb10-mitoferrin","predicate":"stabilizes","statement":"Abcb10 interacted with Mfrn1, enhanced its stability and promoted Mfrn1-dependent mitochondrial iron import.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fd32e6f7-d600-5c6f-945c-6334bf6c1f71","mechanism_event_label":"An interacting protein helps keep the iron importer available.","subject":{"id":"3e952ec5-d906-5b38-9ba2-ab9028e678b6","slug":"mouse-abcb10","display_name":"Mouse mitochondrial ABC transporter / Abcb10","entity_type_key":"protein"},"object":{"id":"dccf941b-8faf-5cca-b531-b3f08f30804a","slug":"mouse-slc25a37","display_name":"Mouse mitoferrin-1 / Slc25a37","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"fd32e6f7-d600-5c6f-945c-6334bf6c1f71","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-abcb10-mitoferrin-event","event_type":"biochemical_relationship","label":"An interacting protein helps keep the iron importer available.","description":"Abcb10 interacted with Mfrn1, enhanced its stability and promoted Mfrn1-dependent mitochondrial iron import.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"59d6d1cd-df32-5b58-b950-3188bc7b95d6","slug":"iron-ii","display_name":"Ferrous iron","entity_type_key":"ion"},"role":"imported_metal","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3e952ec5-d906-5b38-9ba2-ab9028e678b6","slug":"mouse-abcb10","display_name":"Mouse mitochondrial ABC transporter / Abcb10","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"dccf941b-8faf-5cca-b531-b3f08f30804a","slug":"mouse-slc25a37","display_name":"Mouse mitoferrin-1 / Slc25a37","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iron-research/19805291.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d513c833380932eae7a3667fae0e77d5bc7c03067c266e62438d8a63e3839955\", \"start_char\": 0, \"end_char\": 1697, \"text_sha256\": \"d513c833380932eae7a3667fae0e77d5bc7c03067c266e62438d8a63e3839955\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Affinity purification, mass spectrometry and expression experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Abcb10/Mfrn1 expression during differentiation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Stabilization and transport were measured in cell systems, not supplementation experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse erythroleukemia cells and heterologous COS7 cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An interacting protein helps keep the iron importer available.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iron-p19805291] Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. (2009). https://pubmed.ncbi.nlm.nih.gov/19805291/ DOI: 10.1073/pnas.0904519106","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial inner membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2ed5be33-59e4-5191-b6a5-d798b855a1b8","evidence_kind":"source_excerpt","locator":"Lines 485-496","start_line":485,"end_line":496,"excerpt":"### iron-abcb10-mitoferrin\nAbcb10 interacted with Mfrn1, enhanced its stability and promoted Mfrn1-dependent mitochondrial iron import.\nCondition category: normal\nnutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An interacting protein helps keep the iron importer available.\norganism: Mouse erythroleukemia cells and heterologous COS7 cells\ntissue_or_cell_type: Mitochondrial inner membrane\nexperimental_model: Affinity purification, mass spectrometry and expression experiments\nlimitations: Stabilization and transport were measured in cell systems, not supplementation experiments.\nexposure: Abcb10/Mfrn1 expression during differentiation\nevidence_span: {\"source_cache\": \"artifacts/iron-research/19805291.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d513c833380932eae7a3667fae0e77d5bc7c03067c266e62438d8a63e3839955\", \"start_char\": 0, \"end_char\": 1697, \"text_sha256\": \"d513c833380932eae7a3667fae0e77d5bc7c03067c266e62438d8a63e3839955\"}\n[iron-p19805291] Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. (2009). https://pubmed.ncbi.nlm.nih.gov/19805291/ DOI: 10.1073/pnas.0904519106","model_system":"Affinity purification, mass spectrometry and expression experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iron-p19805291] Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. (2009). https://pubmed.ncbi.nlm.nih.gov/19805291/ DOI: 10.1073/pnas.0904519106","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1560864c-91d1-58dc-90c4-49bf61aba3de","stable_key":"import-e13b03e1-a614-543a-ac1b-97df18cfe30d","title":"Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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