{"id":"681faabc-5453-5334-a2ed-c12f9dec1c30","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-endothelial-chemokine","predicate":"induces_tested","statement":"Insulin-stimulated arterial endothelial cells upregulated CX3CL1.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"00243327-f2fe-5a54-990f-8d2593fc8636","mechanism_event_label":"A hormone can change an immune-cell recruitment signal.","subject":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"object":{"id":"57072c13-fc08-579d-90af-1e28eb87eac5","slug":"2025-arterial-cell-cx3cl1","display_name":"Arterial-cell CX3CL1 in the 2025 aspartame study, species unresolved","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"00243327-f2fe-5a54-990f-8d2593fc8636","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-endothelial-chemokine-event","event_type":"observed_relationship","label":"A hormone can change an immune-cell recruitment signal.","description":"Insulin-stimulated arterial endothelial cells upregulated CX3CL1.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"57072c13-fc08-579d-90af-1e28eb87eac5","slug":"2025-arterial-cell-cx3cl1","display_name":"Arterial-cell CX3CL1 in the 2025 aspartame study, species unresolved","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Arterial endothelial-cell expression profiling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell species unresolved in accessed abstract; direct aspartame exposure is not asserted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A hormone can change an immune-cell recruitment signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39978336/ · DOI 10.1016/j.cmet.2025.01.006","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cca1d66c-d9f0-5160-a404-05d465c5028c","evidence_kind":"source_excerpt","locator":"Lines 274-280","start_line":274,"end_line":280,"excerpt":"## aspartame-endothelial-chemokine\nA hormone can change an immune-cell recruitment signal.\nInsulin-stimulated arterial endothelial cells upregulated CX3CL1.\nModel: Arterial endothelial-cell expression profiling.\nLimitations: Cell species unresolved in accessed abstract; direct aspartame exposure is not asserted.\nEvidence access: Primary abstract\nSweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39978336/ · DOI 10.1016/j.cmet.2025.01.006","model_system":"Arterial endothelial-cell expression profiling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"21cfc6808062c6ea1fb5d34128bcd005d31f0f6c0d63484794238db77d32ae97","revision_id":"1255dda8-df99-5d4b-a65b-4144c47d7d9b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}