{"id":"68011304-8b88-5c00-8892-32949d158d6c","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-myod-translation","predicate":"required_for_translation","statement":"Satellite-cell eIF5A knockout reduced MyoD translation and impaired the spermidine-associated activation response.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b24876c8-2358-5ec5-b57f-7e52b5277f96","mechanism_event_label":"A specific muscle-regulating protein is a translation target.","subject":{"id":"d220a16a-9534-52fd-a43c-cc577f7bc4aa","slug":"mouse-eif5a","display_name":"Mouse eIF5A translation factor","entity_type_key":"protein"},"object":{"id":"0f2c901a-8d4b-5fc0-840b-a4557e132049","slug":"mouse-myod1","display_name":"Mouse myogenic differentiation 1 / Myod1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"b24876c8-2358-5ec5-b57f-7e52b5277f96","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-myod-translation-event","event_type":"observed_relationship","label":"A specific muscle-regulating protein is a translation target.","description":"Satellite-cell eIF5A knockout reduced MyoD translation and impaired the spermidine-associated activation response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d220a16a-9534-52fd-a43c-cc577f7bc4aa","slug":"mouse-eif5a","display_name":"Mouse eIF5A translation factor","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0f2c901a-8d4b-5fc0-840b-a4557e132049","slug":"mouse-myod1","display_name":"Mouse myogenic differentiation 1 / Myod1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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