{"id":"67e7254a-e5a6-5288-b3a3-21041f0a4d44","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-asthma-challenge","predicate":"does_not_induce_demonstrated","statement":"A blinded crossover in twelve adults reporting MSG-associated asthma found no definite immediate or late asthmatic reaction to 1 g or 5 g MSG versus lactose placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"b85ae72d-659d-5625-825b-c913f3566e66","mechanism_event_label":"Time-matched baseline variation changed interpretation of a lung-function fall.","subject":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"object":{"id":"ffee0698-95ed-5b5e-813f-acfadc3ff402","slug":"human-msg-asthma-challenge-response","display_name":"Human asthma response during controlled MSG challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b85ae72d-659d-5625-825b-c913f3566e66","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-asthma-challenge-event","event_type":"observed_relationship","label":"Time-matched baseline variation changed interpretation of a lung-function fall.","description":"A blinded crossover in twelve adults reporting MSG-associated asthma found no definite immediate or late asthmatic reaction to 1 g or 5 g MSG versus lactose placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ffee0698-95ed-5b5e-813f-acfadc3ff402","slug":"human-msg-asthma-challenge-response","display_name":"Human asthma response during controlled MSG challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Fasted capsule challenges with three control days and spirometry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small study; does not establish universal absence of reactions or identify an immune mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Time-matched baseline variation changed interpretation of a lung-function fall.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate-intolerant. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9648703/ · DOI 10.1016/s0091-6749(98)70305-7","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"efaee80b-5812-52e4-85f0-22a4b84a85c2","evidence_kind":"source_excerpt","locator":"Lines 274-280","start_line":274,"end_line":280,"excerpt":"## monosodium-glutamate-asthma-challenge\nTime-matched baseline variation changed interpretation of a lung-function fall.\nA blinded crossover in twelve adults reporting MSG-associated asthma found no definite immediate or late asthmatic reaction to 1 g or 5 g MSG versus lactose placebo.\nModel: Fasted capsule challenges with three control days and spirometry.\nLimitations: Small study; does not establish universal absence of reactions or identify an immune mechanism.\nEvidence access: Primary abstract\nThe effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate-intolerant. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9648703/ · DOI 10.1016/s0091-6749(98)70305-7","model_system":"Fasted capsule challenges with three control days and spirometry.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"90a81fe5-8622-52f6-b4db-04899206c2b0","stable_key":"import-561b2b40-5b59-548f-a749-f357f7e2304c","title":"Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"53052c19ee82d400eff7d82ffa3cff74747c7f91a8d173efa3f46eba6bd87cce","revision_id":"fdb64139-32f4-537e-bb0f-f242f2779da8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}