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(2022). https://pubmed.ncbi.nlm.nih.gov/35978954/ DOI: 10.3389/fnut.2022.954593","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"HDL fractions and plasma lipoproteins","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8d54c286-d1c5-5ff7-9f97-f6e65164101a","evidence_kind":"source_excerpt","locator":"Lines 1040-1051","start_line":1040,"end_line":1051,"excerpt":"### lycopene-hdl-cetp\nSupplementation reduced CETP activity in HDL2 and HDL3 fractions.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A lipid-transfer measurement changed without proving the whole pathway is beneficial.\norganism: Human, 225 adults aged 40-65 years\ntissue_or_cell_type: HDL fractions and plasma lipoproteins\nexperimental_model: Randomized diet/supplement trial biomarker analysis\nlimitations: Food and supplement doses differ; enzyme activities and particle sizes are surrogate endpoints, not proof of fewer events.\nexposure: Low tomato control; 224-350 mg/week food lycopene; or 70 mg/week supplement\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/35978954.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ed024b652760ea2f5ab124162690901b3e88995ea9648bea05b59f240de08c3a\", \"start_char\": 0, \"end_char\": 2778, \"text_sha256\": \"ed024b652760ea2f5ab124162690901b3e88995ea9648bea05b59f240de08c3a\"}\n[lycopene-p35978954] Lycopene-rich diets modulate HDL functionality and associated inflammatory markers without affecting lipoprotein size and distribution in moderately overweight, disease-free, middle-aged adults: A randomized controlled trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35978954/ DOI: 10.3389/fnut.2022.954593","model_system":"Randomized diet/supplement trial biomarker analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lycopene-p35978954] Lycopene-rich diets modulate HDL functionality and associated inflammatory markers without affecting lipoprotein size and distribution in moderately overweight, disease-free, middle-aged adults: A randomized controlled trial. 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