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(2021). https://pubmed.ncbi.nlm.nih.gov/32839513/ DOI: 10.1038/s41380-020-00862-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hippocampal dentate-gyrus-like neuronal progenitors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"597a88f4-3362-5e0f-9a53-764656c90443","evidence_kind":"source_excerpt","locator":"Lines 1276-1287","start_line":1276,"end_line":1287,"excerpt":"### ino-impa1-myo-rescue\nMyo-inositol supplementation of differentiation medium rescued the reported neuronal-progenitor phenotype in IMPA1-deficient patient-derived cultures.\nCondition category: machinery_impairment\nnutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Providing the missing downstream molecule helped cells in culture; clinical benefit remains untested here.\norganism: Homo sapiens\ntissue_or_cell_type: Hippocampal dentate-gyrus-like neuronal progenitors\nexperimental_model: Patient-derived iPSC differentiation and rescue\nlimitations: Cellular rescue is not demonstrated neurological benefit in treated patients; effects were lineage-specific.\nexposure: Biallelic IMPA1 defect and myo-inositol-supplemented medium\nevidence_span: {\"source_cache\": \"artifacts/inositol-research/32839513.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5ca10517672cac78ad8cdb0c593f14f73f1989e55977432d979690eebc3eefed\", \"start_char\": 0, \"end_char\": 1711, \"text_sha256\": \"5ca10517672cac78ad8cdb0c593f14f73f1989e55977432d979690eebc3eefed\"}\n[ino-p32839513] Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. 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