{"id":"676d4c42-3371-565c-bc05-8b6238aadbc4","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-tea-bacterial-response","predicate":"increases_assayed","statement":"After tea consumption, peripheral gamma-delta T cells showed IFN-gamma responses to bacteria.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"48c7e665-7283-525d-8a58-5b4cc5f10d8e","mechanism_event_label":"An immune-cell assay does not directly measure whether people catch fewer infections.","subject":{"id":"1ab5fe6d-40a7-576a-b4dd-74af5d399e1b","slug":"tea-beverage","display_name":"Tea beverage, study-specific composition","entity_type_key":"chemical_species"},"object":{"id":"3e0e9fed-2f5d-518d-9b43-709e7a2e8eda","slug":"bacterial-stimulated-ifng-secretion","display_name":"Bacteria-stimulated gamma-delta T-cell IFN-gamma secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"48c7e665-7283-525d-8a58-5b4cc5f10d8e","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-tea-bacterial-response-event","event_type":"observed_intervention","label":"An immune-cell assay does not directly measure whether people catch fewer infections.","description":"After tea consumption, peripheral gamma-delta T cells showed IFN-gamma responses to bacteria.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1ab5fe6d-40a7-576a-b4dd-74af5d399e1b","slug":"tea-beverage","display_name":"Tea beverage, study-specific composition","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3e0e9fed-2f5d-518d-9b43-709e7a2e8eda","slug":"bacterial-stimulated-ifng-secretion","display_name":"Bacteria-stimulated gamma-delta T-cell IFN-gamma secretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/theanine-research/12719524.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5597ffe96859e7675adb765468cef7d5809b7874501b43cff49a1c4b866987b9\", \"start_char\": 0, \"end_char\": 1161, \"text_sha256\": \"5597ffe96859e7675adb765468cef7d5809b7874501b43cff49a1c4b866987b9\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cell priming and tea-consumption immune assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Alkylamine priming in vitro; tea consumption in humans","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Tea has many constituents. The study does not isolate theanine as the cause or establish clinical infection prevention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Theanine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human gamma-delta T cells and tea drinkers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An immune-cell assay does not directly measure whether people catch fewer infections.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[theanine-p12719524] Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. (2003). https://pubmed.ncbi.nlm.nih.gov/12719524/ DOI: 10.1073/pnas.1035603100","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Ex-vivo immune response to ethylamine and bacteria","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"10f263d7-ff7e-5c1e-bd33-65bc8637e478","evidence_kind":"source_excerpt","locator":"Lines 861-872","start_line":861,"end_line":872,"excerpt":"### theanine-tea-bacterial-response\nAfter tea consumption, peripheral gamma-delta T cells showed IFN-gamma responses to bacteria.\nCondition category: normal\nnutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An immune-cell assay does not directly measure whether people catch fewer infections.\norganism: Human gamma-delta T cells and tea drinkers\ntissue_or_cell_type: Ex-vivo immune response to ethylamine and bacteria\nexperimental_model: Human cell priming and tea-consumption immune assays\nlimitations: Tea has many constituents. The study does not isolate theanine as the cause or establish clinical infection prevention.\nexposure: Alkylamine priming in vitro; tea consumption in humans\nevidence_span: {\"source_cache\": \"artifacts/theanine-research/12719524.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5597ffe96859e7675adb765468cef7d5809b7874501b43cff49a1c4b866987b9\", \"start_char\": 0, \"end_char\": 1161, \"text_sha256\": \"5597ffe96859e7675adb765468cef7d5809b7874501b43cff49a1c4b866987b9\"}\n[theanine-p12719524] Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. 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