{"id":"6739e02e-7b64-5f89-b602-a3a4303325d9","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-disulfidptosis-wave","predicate":"supports_tested","statement":"Inactivation of the WAVE regulatory complex suppressed disulfidptosis, whereas constitutive Rac activation promoted it in the studied cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8ac85141-a0dc-5211-b4a3-8a92a231c249","mechanism_event_label":"The state of the actin-assembly machinery changed vulnerability to sulfur stress.","subject":{"id":"52275cef-3da6-5dbe-89da-4e84da54ca4f","slug":"human-wave-regulatory-complex","display_name":"Human WAVE regulatory complex","entity_type_key":"protein_complex"},"object":{"id":"7721c6a8-51bb-5107-b9bf-0da4884f8cb4","slug":"human-actin-disulfide-collapse","display_name":"Actin-cytoskeleton disulfide bonding and collapse in human cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8ac85141-a0dc-5211-b4a3-8a92a231c249","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-disulfidptosis-wave-event","event_type":"observed_relationship","label":"The state of the actin-assembly machinery changed vulnerability to sulfur stress.","description":"Inactivation of the WAVE regulatory complex suppressed disulfidptosis, whereas constitutive Rac activation promoted it in the studied cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"52275cef-3da6-5dbe-89da-4e84da54ca4f","slug":"human-wave-regulatory-complex","display_name":"Human WAVE regulatory complex","entity_type_key":"protein_complex"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7721c6a8-51bb-5107-b9bf-0da4884f8cb4","slug":"human-actin-disulfide-collapse","display_name":"Actin-cytoskeleton disulfide bonding and collapse in human cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"796fe565-258e-5f25-8057-2772a29294a9","slug":"human-slc7a11-high-disulfide-stress","display_name":"Disulfide stress in SLC7A11-high human cells","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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