{"id":"671af725-86c9-5e16-8505-50e131059c27","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-iron","predicate":"reduces","statement":"In 30 women with low iron stores, 150 and 300 mg EGCG reduced relative nonheme-iron absorption by 14% and 27%; the 300 mg comparison with placebo was significant.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"8977c060-0367-5582-b36a-9d8071b001cc","mechanism_event_label":"EGCG reduced iron absorption at the higher tested dose.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8977c060-0367-5582-b36a-9d8071b001cc","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-iron-event","event_type":"observed_relationship","label":"EGCG reduced iron absorption at the higher tested dose.","description":"In 30 women with low iron stores, 150 and 300 mg EGCG reduced relative nonheme-iron absorption by 14% and 27%; the 300 mg comparison with placebo was significant.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Randomized double-blind three-period crossover; eight days per period; stable iron isotopes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The reassuring paper title does not negate its significant high-dose result. Low-dose impact in healthy iron-replete people was an author extrapolation, not the studied population.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"EGCG reduced iron absorption at the higher tested dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Epigallocatechin gallate (EGCG) (TEAVIGO) does not impair nonhaem-iron absorption in man. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16008116/ · DOI 10.1016/j.phymed.2004.07.001","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2548f7e8-d5f8-5dea-9b0f-4cbdff525548","evidence_kind":"source_excerpt","locator":"Lines 188-194","start_line":188,"end_line":194,"excerpt":"## egcg-iron\nEGCG reduced iron absorption at the higher tested dose.\nIn 30 women with low iron stores, 150 and 300 mg EGCG reduced relative nonheme-iron absorption by 14% and 27%; the 300 mg comparison with placebo was significant.\nModel: Randomized double-blind three-period crossover; eight days per period; stable iron isotopes.\nLimitations: The reassuring paper title does not negate its significant high-dose result. Low-dose impact in healthy iron-replete people was an author extrapolation, not the studied population.\nEvidence access: primary abstract.\nEpigallocatechin gallate (EGCG) (TEAVIGO) does not impair nonhaem-iron absorption in man. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16008116/ · DOI 10.1016/j.phymed.2004.07.001","model_system":"Randomized double-blind three-period crossover; eight days per period; stable iron isotopes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}