{"id":"66fd42fd-61ad-5825-a1f5-4ac1c8b3704d","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-cyp2c9-earlier","predicate":"inhibits","statement":"An earlier CYP assay reported myricetin inhibition of CYP2C9 with IC50 13 micromolar.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"59c81e59-4f09-5c3f-8629-06f3d97026ef","mechanism_event_label":"An earlier enzyme assay reported greater inhibition.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"c96f78f4-5bca-5867-9ac1-652891d40aa0","slug":"cyp2c9","display_name":"Human cytochrome P450 2C9","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"59c81e59-4f09-5c3f-8629-06f3d97026ef","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-cyp2c9-earlier-event","event_type":"observed_relationship","label":"An earlier enzyme assay reported greater inhibition.","description":"An earlier CYP assay reported myricetin inhibition of CYP2C9 with IC50 13 micromolar.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c96f78f4-5bca-5867-9ac1-652891d40aa0","slug":"cyp2c9","display_name":"Human cytochrome P450 2C9","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Enzyme activity testing accompanying a rat carvedilol study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Later recombinant diclofenac assay showed no inhibition at 20 micromolar. Assay differences require matched replication; not a universal clinical interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An earlier enzyme assay reported greater inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of myricetin on the bioavailability of carvedilol in rats. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22132944/ · DOI 10.3109/13880209.2011.611141","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"de6b3320-e63a-56ad-bdb0-729e9c3883c8","evidence_kind":"source_excerpt","locator":"Lines 220-226","start_line":220,"end_line":226,"excerpt":"## myricetin-cyp2c9-earlier\nAn earlier enzyme assay reported greater inhibition.\nAn earlier CYP assay reported myricetin inhibition of CYP2C9 with IC50 13 micromolar.\nModel: Enzyme activity testing accompanying a rat carvedilol study.\nLimitations: Later recombinant diclofenac assay showed no inhibition at 20 micromolar. Assay differences require matched replication; not a universal clinical interaction.\nEvidence access: Primary abstract\nEffects of myricetin on the bioavailability of carvedilol in rats. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22132944/ · DOI 10.3109/13880209.2011.611141","model_system":"Enzyme activity testing accompanying a rat carvedilol study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}