{"id":"66bc0df6-3ab1-5fc5-afd9-a43c26f0b1d4","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-copper-chelator-rescue","predicate":"reduces","statement":"Copper-specific chelators, unlike tested iron/zinc chelators, inhibited resveratrol-associated DNA breakage in isolated human lymphocyte and nuclear experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d48a3377-face-5928-973b-97d3c461a6af","mechanism_event_label":"A metal-specific rescue helps identify the assay mechanism.","subject":{"id":"9da0c0b5-b787-5c1f-8830-4e77abfd4a42","slug":"copper-specific-chelation","display_name":"Copper-specific chelation","entity_type_key":"cellular_process"},"object":{"id":"f03ea8e9-5832-5e47-9bc6-af5c3152abfb","slug":"human-lymphocyte-resveratrol-dna-breakage","display_name":"Resveratrol-associated DNA breakage in isolated human lymphocytes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d48a3377-face-5928-973b-97d3c461a6af","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-copper-chelator-rescue-event","event_type":"observed_relationship","label":"A metal-specific rescue helps identify the assay mechanism.","description":"Copper-specific chelators, unlike tested iron/zinc chelators, inhibited resveratrol-associated DNA breakage in isolated human lymphocyte and nuclear experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9da0c0b5-b787-5c1f-8830-4e77abfd4a42","slug":"copper-specific-chelation","display_name":"Copper-specific chelation","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f03ea8e9-5832-5e47-9bc6-af5c3152abfb","slug":"human-lymphocyte-resveratrol-dna-breakage","display_name":"Resveratrol-associated DNA breakage in isolated human lymphocytes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2a870bb5-05a0-5e51-a70c-a9a843a8b571","slug":"copper-ii","display_name":"Copper(II) ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated cells, permeabilized cells and nuclei.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cancer-selective killing was a proposed interpretation, not demonstrated clinical benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A metal-specific rescue helps identify the assay mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20119749/ · DOI 10.1007/s11095-010-0055-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c21cf455-557c-5791-8251-199eb595af83","evidence_kind":"source_excerpt","locator":"Lines 390-396","start_line":390,"end_line":396,"excerpt":"## resveratrol-copper-chelator-rescue\nA metal-specific rescue helps identify the assay mechanism.\nCopper-specific chelators, unlike tested iron/zinc chelators, inhibited resveratrol-associated DNA breakage in isolated human lymphocyte and nuclear experiments.\nModel: Isolated cells, permeabilized cells and nuclei.\nLimitations: Cancer-selective killing was a proposed interpretation, not demonstrated clinical benefit.\nEvidence access: Primary abstract\nResveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20119749/ · DOI 10.1007/s11095-010-0055-4","model_system":"Isolated cells, permeabilized cells and nuclei.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}