{"id":"667e8923-2d73-5b50-a5a1-c6b91ee14128","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-human-beta-cleavage-null","predicate":"does_not_appear_to_reduce","statement":"The retinyl-ester response suggested no apparent inhibition of beta-carotene cleavage despite reduced absorption.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8ece2049-837f-5952-83d5-d2e1a97aae06","mechanism_event_label":"Less absorption and blocked vitamin A conversion are different claims.","subject":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"object":{"id":"9b314191-4d6b-58e9-9549-085c545bf181","slug":"beta-carotene-central-cleavage","display_name":"Beta-carotene central cleavage","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8ece2049-837f-5952-83d5-d2e1a97aae06","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-human-beta-cleavage-null-event","event_type":"observed_intervention","label":"Less absorption and blocked vitamin A conversion are different claims.","description":"The retinyl-ester response suggested no apparent inhibition of beta-carotene cleavage despite reduced absorption.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9b314191-4d6b-58e9-9549-085c545bf181","slug":"beta-carotene-central-cleavage","display_name":"Beta-carotene central cleavage","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lutein-research/9857262.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"22d6d633851b14b6c170fecfb2b3ef493c263f1640d690a2ee3a1d3bf9ccc77f\", \"start_char\": 0, \"end_char\": 892, \"text_sha256\": \"22d6d633851b14b6c170fecfb2b3ef493c263f1640d690a2ee3a1d3bf9ccc77f\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Original single-meal volunteer data reported alongside a literature discussion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Beta-carotene alone or combined with lutein; beta-carotene:lutein ratios 2:1 and 1:2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Record uses the original experiment, not the review portion; reduced uptake did not imply impaired cleavage of absorbed beta-carotene.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lutein research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Less absorption and blocked vitamin A conversion are different claims.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lutein-p9857262] Effect of lutein on beta-carotene absorption and cleavage. 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