{"id":"66747d9e-a04e-57a8-84f1-e19f59686981","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-trans-pantothenate-current","predicate":"evokes","statement":"Pantothenate evoked sodium-, concentration- and potential-dependent inward currents in Xenopus oocytes expressing human SLC5A6.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"45a73c7f-3c5e-5cf6-9e07-de352ad62131","mechanism_event_label":"Pantothenate transport through human SMVT moves net positive charge inward.","subject":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"object":{"id":"1f5ff98e-cebb-54e5-bd3b-0876d3fbafee","slug":"slc5a6-pantothenate-evoked-current","display_name":"Pantothenate-evoked SLC5A6 inward current","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"45a73c7f-3c5e-5cf6-9e07-de352ad62131","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-trans-pantothenate-current-event","event_type":"biochemical_relationship","label":"Pantothenate transport through human SMVT moves net positive charge inward.","description":"Pantothenate evoked sodium-, concentration- and potential-dependent inward currents in Xenopus oocytes expressing human SLC5A6.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3bd59e38-e6b1-5223-b4de-faa33835f5bc","slug":"slc5a6","display_name":"Human sodium-dependent multivitamin transporter / SLC5A6","entity_type_key":"protein"},"role":"transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"cotransported_ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1f5ff98e-cebb-54e5-bd3b-0876d3fbafee","slug":"slc5a6-pantothenate-evoked-current","display_name":"Pantothenate-evoked SLC5A6 inward current","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human SMVT cloned from JAR cells, expressed in human retinal pigment epithelial cells and Xenopus laevis oocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Electrophysiology after human SMVT expression; pantothenate and extracellular sodium varied.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Heterologous human-protein experiments establish transport properties; they do not quantify whole-body absorption or nutrient deficiency from supplement competition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens (protein); Xenopus laevis (expression host)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Pantothenate transport through human SMVT moves net positive charge inward.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-trans-wang1999] Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. (1999). https://pubmed.ncbi.nlm.nih.gov/10329687/ DOI: 10.1074/jbc.274.21.14875","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Oocyte plasma membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d71a04b3-dbe7-5afc-9628-5e700c943e00","evidence_kind":"source_excerpt","locator":"Lines 210-221","start_line":210,"end_line":221,"excerpt":"### b5-trans-pantothenate-current\nPantothenate evoked sodium-, concentration- and potential-dependent inward currents in Xenopus oocytes expressing human SLC5A6.\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Pantothenate transport through human SMVT moves net positive charge inward.\norganism: Homo sapiens (protein); Xenopus laevis (expression host)\ntissue_or_cell_type: Oocyte plasma membrane\nexperimental_model: Human SMVT cloned from JAR cells, expressed in human retinal pigment epithelial cells and Xenopus laevis oocytes\nlimitations: Heterologous human-protein experiments establish transport properties; they do not quantify whole-body absorption or nutrient deficiency from supplement competition.\nexposure: Electrophysiology after human SMVT expression; pantothenate and extracellular sodium varied.\ncross_nutrient: true\n[b5-trans-wang1999] Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. (1999). https://pubmed.ncbi.nlm.nih.gov/10329687/ DOI: 10.1074/jbc.274.21.14875","model_system":"Human SMVT cloned from JAR cells, expressed in human retinal pigment epithelial cells and Xenopus laevis oocytes","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-trans-wang1999] Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. 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