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(2024). https://pubmed.ncbi.nlm.nih.gov/38940639/ DOI: 10.1021/acs.biochem.4c00206","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial urea-cycle enzyme","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"65cd74cc-26be-505c-9423-a4527b5b5473","evidence_kind":"source_excerpt","locator":"Lines 203-214","start_line":203,"end_line":214,"excerpt":"### citrulline-otc-citrulline\nHuman OTC converts ornithine and carbamoyl phosphate into citrulline, releasing inorganic phosphate.\nCondition category: normal\nnutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Citrulline is built from ornithine and a nitrogen-containing carbamoyl group.\norganism: Human OTC\ntissue_or_cell_type: Mitochondrial urea-cycle enzyme\nexperimental_model: Recombinant enzyme site-directed mutagenesis and kinetic assays\nlimitations: Recombinant mutation experiments; do not equate altered enzyme function with a dietary shortage.\nexposure: Ornithine and carbamoyl phosphate; active-site and remote variants\nevidence_span: {\"source_cache\": \"artifacts/citrulline-research/38940639.fulltext.txt\", \"locator\": \"Primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5eca9d57812cf3d8efe7c0beb62b9b364cc25e1aeca647c95e4abf0fd9eb8365\", \"start_char\": 194, \"end_char\": 364, \"text_sha256\": \"c5ddbcd5c91cfcdc72d6e556c77228f8ecd6c25ebaa3c25fd9617f6baa145692\"}\n[citrulline-p38940639] Revisiting the Roles of Catalytic Residues in Human Ornithine Transcarbamylase. 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