{"id":"663d33d2-4abd-5f3d-9667-46fab9eff4ec","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:low-calcium-intake-fractional-retention","predicate":"low_intake_increases","statement":"The same diet reduction increased fractional oral 47Ca retention within one week.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"41a9948b-cffe-5a2a-b086-0ee7627e09b9","mechanism_event_label":"The retained fraction adapts to low intake.","subject":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"object":{"id":"f3f15e1c-f692-59f6-a0dd-50249ab4f36c","slug":"fractional-calcium-retention","display_name":"Fractional whole-body calcium retention","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"41a9948b-cffe-5a2a-b086-0ee7627e09b9","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:low-calcium-intake-fractional-retention-event","event_type":"biochemical_relationship","label":"The retained fraction adapts to low intake.","description":"The same diet reduction increased fractional oral 47Ca retention within one week.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"restricted_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"oral_tracer","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f3f15e1c-f692-59f6-a0dd-50249ab4f36c","slug":"fractional-calcium-retention","display_name":"Fractional whole-body calcium retention","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Nine healthy women; controlled 2000-to-300 mg/day calcium diet change and oral 47Ca retention","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Retention indexes absorption; greater fraction does not guarantee adequate absolute uptake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The retained fraction adapts to low intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dawsonhughes1988] Effect of lowering dietary calcium intake on fractional whole body calcium retention (1988). https://pubmed.ncbi.nlm.nih.gov/3132484/ DOI: 10.1210/jcem-67-1-62","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole body","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"28b3c5e7-f340-532b-9fe9-0482d5656a11","evidence_kind":"source_excerpt","locator":"Lines 302-311","start_line":302,"end_line":311,"excerpt":"### low-calcium-intake-fractional-retention\nThe same diet reduction increased fractional oral 47Ca retention within one week.\nCondition category: nutrient_deficiency\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The retained fraction adapts to low intake.\norganism: Homo sapiens\ntissue_or_cell_type: Whole body\nexperimental_model: Nine healthy women; controlled 2000-to-300 mg/day calcium diet change and oral 47Ca retention\nlimitations: Retention indexes absorption; greater fraction does not guarantee adequate absolute uptake.\n[dawsonhughes1988] Effect of lowering dietary calcium intake on fractional whole body calcium retention (1988). https://pubmed.ncbi.nlm.nih.gov/3132484/ DOI: 10.1210/jcem-67-1-62","model_system":"Nine healthy women; controlled 2000-to-300 mg/day calcium diet change and oral 47Ca retention","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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