{"id":"656d8e2b-9512-53a0-9ec6-3cba7e072539","stable_key":"a9828b14-fbd7-57bf-9e01-0d52d1b42a1f:citrulline-short-bowel-low","predicate":"had_lower_circulating_concentration_in","statement":"Mean plasma citrulline was 20 ± 13 micromolar in short-bowel patients versus 40 ± 10 in controls.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a3c1cace-78ef-5a2f-a4bd-e599a3026a20","mechanism_event_label":"A low value can mark reduced intestinal production rather than low dietary intake.","subject":{"id":"f53c7bfb-3b91-56fe-bebd-28623cfe13a0","slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"},"object":{"id":"77ef287f-ecc9-5c9a-ae8b-d102f9024098","slug":"circulating-citrulline-concentration","display_name":"Circulating citrulline concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a3c1cace-78ef-5a2f-a4bd-e599a3026a20","stable_key":"a9828b14-fbd7-57bf-9e01-0d52d1b42a1f:citrulline-short-bowel-low-event","event_type":"biochemical_relationship","label":"A low value can mark reduced intestinal production rather than low dietary intake.","description":"Mean plasma citrulline was 20 ± 13 micromolar in short-bowel patients versus 40 ± 10 in controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f53c7bfb-3b91-56fe-bebd-28623cfe13a0","slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"77ef287f-ecc9-5c9a-ae8b-d102f9024098","slug":"circulating-citrulline-concentration","display_name":"Circulating citrulline concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/citrulline-research/11113071.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e2470fc206e5913038da9bb8d7a38677533224bd369ccd02563cefe760727246\", \"start_char\": 0, \"end_char\": 2196, \"text_sha256\": \"e2470fc206e5913038da9bb8d7a38677533224bd369ccd02563cefe760727246\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Observational diagnostic study after intestinal adaptation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"At least two years after final bowel reconstruction","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The 20 micromolar classifier belongs to this cohort and indication, not a universal dietary deficiency cutoff.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Citrulline research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, 57 adults with short-bowel syndrome and 51 controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A low value can mark reduced intestinal production rather than low dietary intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[citrulline-p11113071] Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. (2000). https://pubmed.ncbi.nlm.nih.gov/11113071/ DOI: 10.1053/gast.2000.20227","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Postabsorptive blood and intestinal absorptive function","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"cbb64d01-1eaa-5755-9a01-4d72c9607994","evidence_kind":"source_excerpt","locator":"Lines 970-981","start_line":970,"end_line":981,"excerpt":"### citrulline-short-bowel-low\nMean plasma citrulline was 20 ± 13 micromolar in short-bowel patients versus 40 ± 10 in controls.\nCondition category: biomarker_context\nnutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A low value can mark reduced intestinal production rather than low dietary intake.\norganism: Human, 57 adults with short-bowel syndrome and 51 controls\ntissue_or_cell_type: Postabsorptive blood and intestinal absorptive function\nexperimental_model: Observational diagnostic study after intestinal adaptation\nlimitations: The 20 micromolar classifier belongs to this cohort and indication, not a universal dietary deficiency cutoff.\nexposure: At least two years after final bowel reconstruction\nevidence_span: {\"source_cache\": \"artifacts/citrulline-research/11113071.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e2470fc206e5913038da9bb8d7a38677533224bd369ccd02563cefe760727246\", \"start_char\": 0, \"end_char\": 2196, \"text_sha256\": \"e2470fc206e5913038da9bb8d7a38677533224bd369ccd02563cefe760727246\"}\n[citrulline-p11113071] Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. (2000). https://pubmed.ncbi.nlm.nih.gov/11113071/ DOI: 10.1053/gast.2000.20227","model_system":"Observational diagnostic study after intestinal adaptation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [citrulline-p11113071] Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. (2000). https://pubmed.ncbi.nlm.nih.gov/11113071/ DOI: 10.1053/gast.2000.20227","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"112fd375-aa2a-59d2-8afd-6b2849bb79ee","stable_key":"import-a9828b14-fbd7-57bf-9e01-0d52d1b42a1f","title":"Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"3720442dbabc28cacefd2145c7c97bfb937df26dca8527fde219ecd3735ed558","revision_id":"41ac8493-b004-59d7-99b3-8a3ca7163d3a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}