{"id":"65339b43-d8a8-54e0-aeb9-e13524751666","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-ddo-loss-nmdar","predicate":"restrains_tested","statement":"Ddo deletion increased NMDA-evoked currents and membrane GluN1/GluN2A in mouse nigral dopamine neurons.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"25ab09b8-984d-571c-bde3-b588fbce68ef","mechanism_event_label":"Prolonged higher D-aspartate was accompanied by receptor remodeling.","subject":{"id":"f3fc3b2e-7748-5a0a-a936-94c47f68a6d2","slug":"mouse-ddo","display_name":"Mouse D-aspartate oxidase / Ddo","entity_type_key":"protein"},"object":{"id":"0dfaac36-ded6-5591-bacc-aef6e58b1135","slug":"mouse-nmda-receptors","display_name":"Mouse NMDA-type receptors, subunits unresolved","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"25ab09b8-984d-571c-bde3-b588fbce68ef","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-ddo-loss-nmdar-event","event_type":"observed_relationship","label":"Prolonged higher D-aspartate was accompanied by receptor remodeling.","description":"Ddo deletion increased NMDA-evoked currents and membrane GluN1/GluN2A in mouse nigral dopamine neurons.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f3fc3b2e-7748-5a0a-a936-94c47f68a6d2","slug":"mouse-ddo","display_name":"Mouse D-aspartate oxidase / Ddo","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0dfaac36-ded6-5591-bacc-aef6e58b1135","slug":"mouse-nmda-receptors","display_name":"Mouse NMDA-type receptors, subunits unresolved","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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