{"id":"64f7c46d-49b3-5464-b124-f8e9cbd727cf","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-enters-enterocytes-by-macropinocytosis","predicate":"is_taken_up_by","statement":"EIPA inhibited uptake in the same system, implicating macropinocytosis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3645c2d5-f0d0-5016-975f-ed9c15c415d3","mechanism_event_label":"EIPA inhibited uptake in the same system, implicating macropinocytosis.","subject":{"id":"6b03a125-209a-5060-8b35-ec9e0e54033c","slug":"nattokinase","display_name":"Nattokinase / subtilisin NAT","entity_type_key":"peptide"},"object":{"id":"5c1f9d76-79b6-51b2-9fee-7dfe05668e15","slug":"macropinocytosis","display_name":"Macropinocytosis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3645c2d5-f0d0-5016-975f-ed9c15c415d3","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-enters-enterocytes-by-macropinocytosis-event","event_type":"biochemical_relationship","label":"EIPA inhibited uptake in the same system, implicating macropinocytosis.","description":"Intestinal epithelium","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6b03a125-209a-5060-8b35-ec9e0e54033c","slug":"nattokinase","display_name":"Nattokinase / subtilisin NAT","entity_type_key":"peptide"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5c1f9d76-79b6-51b2-9fee-7dfe05668e15","slug":"macropinocytosis","display_name":"Macropinocytosis","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Caco-2 cell monolayer and rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nattokinase with EIPA","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"As above. Three pathways were implicated to varying degrees; the report does not apportion them.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Caco-2 cell monolayer and rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"EIPA inhibited uptake in the same system, implicating macropinocytosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Study on the transport and internalisation mechanism of dietary supplement nattokinase in the small intestine using animal and Caco-2 cell monolayer models. 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Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. 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