{"id":"64e9d77a-39e8-5ea5-bcfe-8c3ab0b1ed0e","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-preterm-growth","predicate":"reduces_temporarily","statement":"Weight gain was temporarily lower, with the greatest mean difference −23 g at two weeks.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"5425b1ed-ec7b-5bc9-899a-e96c201cd9e7","mechanism_event_label":"The benefit records retain the measured growth tradeoff.","subject":{"id":"b0b2b697-17e9-5d73-bcb4-b01820360cfa","slug":"caffeine-citrate","display_name":"Caffeine citrate","entity_type_key":"small_molecule"},"object":{"id":"81e112ff-8ad9-534f-8550-a2d3805e4304","slug":"preterm-weight-gain","display_name":"Weight gain in preterm infants","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5425b1ed-ec7b-5bc9-899a-e96c201cd9e7","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-preterm-growth-event","event_type":"observed_relationship","label":"The benefit records retain the measured growth tradeoff.","description":"Weight gain was temporarily lower, with the greatest mean difference −23 g at two weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b0b2b697-17e9-5d73-bcb4-b01820360cfa","slug":"caffeine-citrate","display_name":"Caffeine citrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"81e112ff-8ad9-534f-8550-a2d3805e4304","slug":"preterm-weight-gain","display_name":"Weight gain in preterm infants","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"CAP randomized trial, 2006 infants weighing 500–1250 g at birth; clinical caffeine-citrate therapy versus placebo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Death, ultrasound brain-injury signs and necrotizing enterocolitis did not differ significantly in this report.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The benefit records retain the measured growth tradeoff.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Caffeine therapy for apnea of prematurity. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16707748/ · DOI 10.1056/nejmoa054065","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"506620a0-8de0-57fe-aa7c-c9cbf78c0c0a","evidence_kind":"source_excerpt","locator":"Lines 524-530","start_line":524,"end_line":530,"excerpt":"## caf-preterm-growth\nThe benefit records retain the measured growth tradeoff.\nWeight gain was temporarily lower, with the greatest mean difference −23 g at two weeks.\nModel: CAP randomized trial, 2006 infants weighing 500–1250 g at birth; clinical caffeine-citrate therapy versus placebo.\nLimitations: Death, ultrasound brain-injury signs and necrotizing enterocolitis did not differ significantly in this report.\nEvidence access: Primary abstract\nCaffeine therapy for apnea of prematurity. · 2006 · https://pubmed.ncbi.nlm.nih.gov/16707748/ · DOI 10.1056/nejmoa054065","model_system":"CAP randomized trial, 2006 infants weighing 500–1250 g at birth; clinical caffeine-citrate therapy versus placebo.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"780d73d4abd45a0284d2cc0c646dbe8432ae347362891a4b98a19a61341a7325","revision_id":"f36ffb0a-d6df-522f-b783-5e30214b9e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}