{"id":"64d79207-591b-5071-8579-4bf0e084854a","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-retinyl-t10","predicate":"increases","statement":"Feeding the enriched isomer preparation increased hepatic retinyl ester accumulation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b13648cb-31c2-5ca5-8a78-5bdd99ecb94f","mechanism_event_label":"CLA altered a vitamin A storage compartment.","subject":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"object":{"id":"44567d9e-6034-53fe-9fc1-2ce8a2f137ba","slug":"mouse-hepatic-retinyl-ester-storage","display_name":"Mouse hepatic retinyl ester storage","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b13648cb-31c2-5ca5-8a78-5bdd99ecb94f","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-retinyl-t10-event","event_type":"observed_relationship","label":"CLA altered a vitamin A storage compartment.","description":"Feeding the enriched isomer preparation increased hepatic retinyl ester accumulation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"44567d9e-6034-53fe-9fc1-2ce8a2f137ba","slug":"mouse-hepatic-retinyl-ester-storage","display_name":"Mouse hepatic retinyl ester storage","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"148c57d8-c658-5769-89e8-1194cef2a782","slug":"retinol","display_name":"All-trans-retinol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse dietary isomer comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Accumulation does not establish improved vitamin A function.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"CLA altered a vitamin A storage compartment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Hepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"58c08858-fb23-5df1-8f7b-e09f85ff5506","evidence_kind":"source_excerpt","locator":"Lines 246-252","start_line":246,"end_line":252,"excerpt":"## cla-retinyl-t10\nCLA altered a vitamin A storage compartment.\nFeeding the enriched isomer preparation increased hepatic retinyl ester accumulation.\nModel: Mouse dietary isomer comparison.\nLimitations: Accumulation does not establish improved vitamin A function.\nEvidence access: Primary abstract\nHepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200","model_system":"Mouse dietary isomer comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f9fe73a8a4008d52061c65abe6de7a9806da75f1c478c5adace9387b8ffaad9e","revision_id":"21196d9c-aaab-5fe1-8f32-2987c94289c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}