{"id":"64a5e46d-a8e6-588c-8f74-239f97a3edcb","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-worker-semen-observation","predicate":"no_adverse_association_detected_with","statement":"This worker study did not detect boron-associated adverse semen or measured reproductive-hormone effects, including in its highest-exposure subgroup.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"13dafcf4-b11b-5bca-80fa-f38e97a6292f","mechanism_event_label":"The observed workers did not show the predicted changes in the measured outcomes; this does not cancel the animal toxicity evidence or establish universal safety.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"85ab699e-0e0f-55e7-8959-94f4e48edd36","slug":"semen-quality","display_name":"Semen quality measurements","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"13dafcf4-b11b-5bca-80fa-f38e97a6292f","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-worker-semen-observation-event","event_type":"observed_intervention","label":"The observed workers did not show the predicted changes in the measured outcomes; this does not cancel the animal toxicity evidence or establish universal safety.","description":"This worker study did not detect boron-associated adverse semen or measured reproductive-hormone effects, including in its highest-exposure subgroup.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"85ab699e-0e0f-55e7-8959-94f4e48edd36","slug":"semen-quality","display_name":"Semen quality measurements","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/30143848.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"84c4eb762a64b875d8586c084c3b64e9ec0b2246cba0f05164d94b04d7b26899\", \"start_char\": 0, \"end_char\": 1123, \"text_sha256\": \"84c4eb762a64b875d8586c084c3b64e9ec0b2246cba0f05164d94b04d7b26899\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Occupational observational study; 212 male workers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Extreme-exposure subgroup n=98; estimated daily boron exposure mean 47.17 ± 17.47 mg; blood boron mean 570.6 ± 160.1 ng/g","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observed absence of an association does not prove safety at all exposures or rule out selection, confounding or unmeasured outcomes. Do not extend the authors’ broad safety conclusion beyond the observed data.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The observed workers did not show the predicted changes in the measured outcomes; this does not cancel the animal toxicity evidence or establish universal safety.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p30143848] Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions. (2018). https://pubmed.ncbi.nlm.nih.gov/30143848/ DOI: 10.1007/s00204-018-2296-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Semen and circulating FSH, LH and testosterone","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bd436f22-2269-5090-afb2-e483abf8b9b6","evidence_kind":"source_excerpt","locator":"Lines 1184-1195","start_line":1184,"end_line":1195,"excerpt":"### boron-worker-semen-observation\nThis worker study did not detect boron-associated adverse semen or measured reproductive-hormone effects, including in its highest-exposure subgroup.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The observed workers did not show the predicted changes in the measured outcomes; this does not cancel the animal toxicity evidence or establish universal safety.\norganism: Human\ntissue_or_cell_type: Semen and circulating FSH, LH and testosterone\nexperimental_model: Occupational observational study; 212 male workers\nlimitations: Observed absence of an association does not prove safety at all exposures or rule out selection, confounding or unmeasured outcomes. Do not extend the authors’ broad safety conclusion beyond the observed data.\nexposure: Extreme-exposure subgroup n=98; estimated daily boron exposure mean 47.17 ± 17.47 mg; blood boron mean 570.6 ± 160.1 ng/g\nevidence_span: {\"source_cache\": \"artifacts/boron-research/30143848.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"84c4eb762a64b875d8586c084c3b64e9ec0b2246cba0f05164d94b04d7b26899\", \"start_char\": 0, \"end_char\": 1123, \"text_sha256\": \"84c4eb762a64b875d8586c084c3b64e9ec0b2246cba0f05164d94b04d7b26899\"}\n[boron-p30143848] Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions. (2018). https://pubmed.ncbi.nlm.nih.gov/30143848/ DOI: 10.1007/s00204-018-2296-7","model_system":"Occupational observational study; 212 male workers","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p30143848] Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions. (2018). https://pubmed.ncbi.nlm.nih.gov/30143848/ DOI: 10.1007/s00204-018-2296-7","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"0a32c1c5c70cfb4a378f6ace35cf5b75d90ed3065ada91b9f9f64015d603c8e3","revision_id":"38f316f2-4344-542e-a638-0ac5402f678d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}