{"id":"64997656-78a6-5012-ba86-dc542953fe39","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-ankaflavin-ppara","predicate":"increases_tested_expression_of","statement":"Ankaflavin increased hepatic PPAR-alpha expression and promoted a fatty-acid-oxidation program in the mouse study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ca9a76cc-ef57-5035-98e0-e1fe67403197","mechanism_event_label":"A transcriptional program provides a distinct route from statin inhibition.","subject":{"id":"92939faa-84d1-52e8-a70f-deefd2486d52","slug":"ankaflavin","display_name":"Ankaflavin","entity_type_key":"small_molecule"},"object":{"id":"82da9a4a-69b5-5680-abb1-5fa6d0df95a0","slug":"mouse-ppara","display_name":"Mouse peroxisome proliferator-activated receptor alpha / Ppara","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"ca9a76cc-ef57-5035-98e0-e1fe67403197","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-ankaflavin-ppara-event","event_type":"observed_relationship","label":"A transcriptional program provides a distinct route from statin inhibition.","description":"Ankaflavin increased hepatic PPAR-alpha expression and promoted a fatty-acid-oxidation program in the mouse study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"92939faa-84d1-52e8-a70f-deefd2486d52","slug":"ankaflavin","display_name":"Ankaflavin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"82da9a4a-69b5-5680-abb1-5fa6d0df95a0","slug":"mouse-ppara","display_name":"Mouse peroxisome proliferator-activated receptor alpha / Ppara","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8045f158-6679-5caf-bf7c-c590e40176b1","slug":"mouse-ppargc1a","display_name":"Mouse PGC-1alpha / Ppargc1a","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"High-fat-diet C57BL/6 mice; related mouse FL83B hepatocyte experiments also reported.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The paper describes agonist activity; the accessed abstract does not resolve direct receptor affinity or establish a human clinical effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A transcriptional program provides a distinct route from statin inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[24275089] Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24275089/ · DOI 10.1016/j.fct.2013.11.015","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"40a018b9-209d-535d-94dc-7ec6ed6ce275","evidence_kind":"source_excerpt","locator":"Lines 228-234","start_line":228,"end_line":234,"excerpt":"## red-yeast-rice-ankaflavin-ppara\nA transcriptional program provides a distinct route from statin inhibition.\nAnkaflavin increased hepatic PPAR-alpha expression and promoted a fatty-acid-oxidation program in the mouse study.\nModel: High-fat-diet C57BL/6 mice; related mouse FL83B hepatocyte experiments also reported.\nLimitations: The paper describes agonist activity; the accessed abstract does not resolve direct receptor affinity or establish a human clinical effect.\nEvidence access: Primary abstract\n[24275089] Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24275089/ · DOI 10.1016/j.fct.2013.11.015","model_system":"High-fat-diet C57BL/6 mice; related mouse FL83B hepatocyte experiments also reported.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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