{"id":"6450ba2f-de3d-5d08-afc1-1509003c4931","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-formate-serine-deprived-rescue","predicate":"rescues_tested","statement":"Formate restored nucleotide synthesis and growth in glycine-fed cells lacking serine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"48306bb1-9dae-52c8-96e3-eb6aa7b64f24","mechanism_event_label":"Another input changed whether supplied glycine could support growth.","subject":{"id":"1fc1fa42-fcb5-5983-9a31-114703dc64c4","slug":"formate","display_name":"Formate","entity_type_key":"small_molecule"},"object":{"id":"0379ca78-204b-554d-b7b5-07d3d95db74d","slug":"serine-deprived-glycine-fed-growth","display_name":"Growth of glycine-fed serine-deprived cancer cultures","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"48306bb1-9dae-52c8-96e3-eb6aa7b64f24","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-formate-serine-deprived-rescue-event","event_type":"observed_relationship","label":"Another input changed whether supplied glycine could support growth.","description":"Formate restored nucleotide synthesis and growth in glycine-fed cells lacking serine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1fc1fa42-fcb5-5983-9a31-114703dc64c4","slug":"formate","display_name":"Formate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0379ca78-204b-554d-b7b5-07d3d95db74d","slug":"serine-deprived-glycine-fed-growth","display_name":"Growth of glycine-fed serine-deprived cancer cultures","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cancer-cell nutrient and formate rescue experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No extrapolation to treating cancer or supplement combinations in people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Another input changed whether supplied glycine could support growth.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24813884/ · DOI 10.1016/j.celrep.2014.04.045","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d9c41399-d2b8-5cbf-9f8d-c5dade6fed8a","evidence_kind":"source_excerpt","locator":"Lines 186-192","start_line":186,"end_line":192,"excerpt":"## glycine-formate-serine-deprived-rescue\nAnother input changed whether supplied glycine could support growth.\nFormate restored nucleotide synthesis and growth in glycine-fed cells lacking serine.\nModel: Cancer-cell nutrient and formate rescue experiment.\nLimitations: No extrapolation to treating cancer or supplement combinations in people.\nEvidence access: Primary abstract\nSerine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24813884/ · DOI 10.1016/j.celrep.2014.04.045","model_system":"Cancer-cell nutrient and formate rescue experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7b2859d8-e2bf-51e7-8e32-0715c10cbc49","stable_key":"import-507ed066-fd6d-5722-9223-97b66302e7e3","title":"Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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