{"id":"63d87034-922d-5870-a238-853e1ccd83c4","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-human-gut-motor","predicate":"changes","statement":"The higher intraduodenal phenylalanine load suppressed antral and increased phasic pyloric pressures; duodenal pressures and tonic pyloric pressure were not significantly changed.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bbe6f956-f665-523e-8699-06aa86b95ce1","mechanism_event_label":"The stomach-outlet motor response was selective, not a shutdown of all gut movement.","subject":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"object":{"id":"06e399b5-ecfc-5ef6-82bc-cfc70c99052c","slug":"human-phe-antropyloric-motility","display_name":"Human antropyloric motility during phenylalanine infusion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bbe6f956-f665-523e-8699-06aa86b95ce1","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-human-gut-motor-event","event_type":"observed_relationship","label":"The stomach-outlet motor response was selective, not a shutdown of all gut movement.","description":"The higher intraduodenal phenylalanine load suppressed antral and increased phasic pyloric pressures; 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duodenal pressures and tonic pyloric pressure were not significantly changed.\nModel: Ten healthy men; 0.45 kcal/min intraduodenal infusion for 90 minutes.\nLimitations: Gastric emptying was inferred from motor effects rather than directly measured in this experiment.\nEvidence access: Primary full text\nEffects of Intraduodenal Infusions of L-phenylalanine and L-glutamine on Antropyloroduodenal Motility and Plasma Cholecystokinin in Healthy Men. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26130636/ · DOI 10.5056/jnm14143","model_system":"Ten healthy men; 0.45 kcal/min intraduodenal infusion for 90 minutes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54de7c56-1e60-5d7b-8ef9-852c58ae92ba","stable_key":"import-56f1d914-e7da-595a-af69-c217b2b47407","title":"L-Phenylalanine: transport, protein synthesis, cofactor recycling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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