{"id":"63962826-c7eb-55cc-9cb8-7e390d2593b5","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:orexin-null-wake","predicate":"increases_in_recorded_experiment","statement":"Orexin-null mice retained and in one experiment showed greater wake prolongation after modafinil.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8958c0e9-41c5-5b12-b250-a6ef205ccbc2","mechanism_event_label":"Orexin-null mice retained and in one experiment showed greater wake prolongation after modafinil.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"2783faf9-3c82-5360-8540-e30f0f7310a1","slug":"mouse-wake-duration","display_name":"Mouse wake duration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8958c0e9-41c5-5b12-b250-a6ef205ccbc2","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:orexin-null-wake-event","event_type":"experimental_observation","label":"Orexin-null mice retained and in one experiment showed greater wake prolongation after modafinil.","description":"Orexin-null mice retained—and in one experiment showed greater—wake prolongation after modafinil. However, direct wake-to-REM transitions were not suppressed, and an EEG correlate of alertness was only partly restored. Thus, **wake duration, cataplexy-related phenomena and quality of alertness are separable**. An intact orexin system was unnecessary for one endpoint, not irrelevant to every endpoint. 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The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Orexin-null mice retained and in one experiment showed greater wake prolongation after modafinil.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. | 2005 | DOI 10.1016/j.neuroscience.2004.10.005 | PMID 15652995 | https://pubmed.ncbi.nlm.nih.gov/15652995/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 81-81; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4373cfd5-84ed-5a8c-880f-aad56e84a948","evidence_kind":"source_excerpt","locator":"Lines 81-81","start_line":81,"end_line":81,"excerpt":"Orexin-null mice retained—and in one experiment showed greater—wake prolongation after modafinil. However, direct wake-to-REM transitions were not suppressed, and an EEG correlate of alertness was only partly restored. Thus, **wake duration, cataplexy-related phenomena and quality of alertness are separable**. An intact orexin system was unnecessary for one endpoint, not irrelevant to every endpoint. [Orexin-null experiment](https://pubmed.ncbi.nlm.nih.gov/15652995/)","model_system":"Orexin-null versus wild-type mice; genetic loss not dietary deficit.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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